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2. OBJECTIVES 10/13/2015Prof. Mazen Qato2

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4. Basic PK Definitions and Principles  Volume of distribution (Vd)  Elimination constant (Ke) and half-life (t1/2)  “Steady state”  Loading dose

5. Volume of Distribution A proportional constant that relates the amount of drug in the body to the serum concentration If you know a drug’s Vd, you can determine how much of the drug should be given to achieve a desired plasma concentration.

6. 10/13/20156Prof. Mazen Qato

7. Vd = Dose/C O Co= CONCETRATION OF DRUG AT ZERO TIME -If you know the dose and the peak plasma concentration, you can calculate the patients Vd. -If you know the Vd and have a goal plasma concentration, you can calculate the dose

8. FACTORS AFFECTING THE RATE OF DRUG DISTRIBUTION 1. LIPID SOLUBILITY (Kp) 2. IONISATION CONSTANT 3. MOLECULAR WEIGHT 4. BLOOD FLOW 10/13/2015Prof. Mazen Qato8

9. FACTORS AFFECTING THE EXTENT OF DRUG DISTRIBUTATION 10/13/2015Prof. Mazen Qato9

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18. THANK YOU 10/13/2015Prof. Mazen Qato18