1. HEALTH INFORMATICS ENTREPRENEURSHIP SHARING EXPERIENCE FROM BENCH TO BEDSIDE Eric King, CEO & Cofounder

2. 2 0 EHR in Hospital System GRT Knowledge Discovery Cloud Service:

3. 3 Over 20 million patient claims Over 8 million publicly available medical articles Medical reference content Standardized map of medical concepts from NIH

4. 4 GRT (143 Similar Cases) 24 YO African American female with sickle cell anemia presents with jaundice CC: abdominal discomfort

5. 5 GRT80% GRT30% GRT (143 Similar Cases)

6. 6 Past Medical History Relevance Einstein ED visit 2 months ago: Cholecystitis Cholecystitis linked to Abdominal pain Past Medical History Potentially Relevant to Chief Complaint of Abdominal Pain More info EHR

7. 7 Review the Possibilities Build the Case Explore next steps to narrow the differential

8. 1) CARVING OUT THE UNDERLYING PROBLEM

9. 2) IDENTIFYING HIGHEST YIELD SOLUTIONS

10. 3) VALIDATION THROUGH BACK-TESTING True label Predicted label

11. 4) FIELD TESTING Time 1: Past Medical History Time 2: Imaging Results Residents: Hepatitis Biliary Obstruction Hepatic Sequestrtatio n Cholestasis as complication of Sickle Cell Residents: Obstructive Jaundice

12. THE FUTURE OF MEDICINE IS NOW "The application of what we know already will have a bigger impact on health and disease than any drug or technology likely to be introduced in the next decade" --Dr. Muir Gray, Director of Clinical Knowledge for the UK’s National Health Service (NHS)