1. University of Delaware July 6, 2010 Proof-of-Concept, SBIR/STTR Funding, and Business Incubation

2. …To maximize the value of early-stage technology generated by researchers across the Region, and accelerate technology commercialization. The Science Center catalyzes convergence of early-stage technology, funding, entrepreneurs, facilities, and business services in the Greater Philadelphia technology “ecosystem”… Raw Idea (”Push”) Market Ready Idea (“Pull”) Life Science Research Institutions Life Science Research Institutions Life Science Corporations The Science Center’s Programs Help to Bridge the Region’s Demand and Supply of Life Science Technology 2

3. Science and Technology Programs Science and Technology activities include the design and implementation of technology commercialization programs  QED Proof-of-Concept Program: Supports commercially-relevant technology development at stakeholder academic research institutions (Discover and Prove)  Grants and New Ventures: Assists in grant-based formation of new commercial entities from stakeholder institutions, and provides service-based support for existing entities (Develop)  Port Incubators: Provides infrastructure and services to new companies, supports and evaluates company growth, assists company exits (Deploy) Programs seek to interface science and business communities, including academia, industry, investors, and entrepreneurs 3

4. 4 Contact Us For more information on: Obtaining proof-of-concept support Starting new (or working with existing) small businesses using SBIR/STTR funding Accessing business services, expertise, or infrastructure Christopher Laing, MRCVS, PhD claing@sciencecenter.org Or through your Office of Research Administration or Office of Technology Transfer

5. quod erat demonstrandum: “that which was to be demonstrated is demonstrated” Greater Philadelphia’s First Multi-Institute Proof of Concept Program Program Overview University of Delaware July 6, 2010

6. Bridging the Gaps in Technology Transfer QED Program Objective: Increase the commercial value of university life science technology in the Greater Philadelphia Region –Facilitating R&D activities that reduce business risk and increase investment attractiveness –Using existing Regional resources including university technology, business and industry advisors, and bridge funding 6

7. Key Structural Elements of the QED Program Commercially oriented technology development University Based PIs QED-assigned business advisors University Tech Transfer Offices Market-driven selection Effective, efficient, and transparent process Industry, investor, and scientific reviewers Bridge Funding $200,000 per project over 12 months Science Center contribution plus institutional match Guidance to Exit Project monitoring during funding period Program staff and industry participants provide support during pursuit of follow-on funding A coordinated effort to succeed (or fail) “faster and cheaper” 7

8. QED Process Flow and Implementation Application (PIs) RFP (Semi Annual) White Paper Application Project Implementation (PIs and BAs) Proof of Concept Plan Development (PIs and BAs) Follow-on funding opportunities in the private sector (Industry and Investors) 2 mo 2-3 mo 12 mo Finalists Awardees

9. 9 Program Progress to Date Metric Research Institutes17 Proposals134 Phase 1 Finalists20 Phase 2 Funded Projects6 CHOP Drexel Fox Chase Lankenau Rutgers Temple Thomas Jefferson U Del U Sciences Phila U Penn ProjectInstitutionTechnology NIR Wound monitorDrexelDiagnostic device Breast cancer detectorDrexelDiagnostic device Sol-gel drug delivery platformPennCombination therapy Magnetic np drug delivery systemCHOPCombination therapy Heart valve replacementPennImplantable device U1 gene silencingRutgersTherapeutic/research Medical Devices/ Imaging 9 IVD/Research Tools 4 Biologics/ Therapeutics 7

10. The QED Process: Submit a White Paper Next RFP will be released in June 2010 Science Center QED Website (www.sciencecenter.org/qed-rfp)www.sciencecenter.org/qed-rfp Your Technology Transfer Office Talk to your TTO Now, or as soon as you think you may be interested Before you begin to prepare an application Prepare and submit a White Paper Instructions available at the QED website Submit to your TTO via an upload function White Paper review Market representatives 8-10 applicants invited to prepare a full-proposal (September, 2010) 10

11. Components of a White Paper Application  Technology Description  Brief summary of the technical merits of your innovation  List the features and benefits  Market Opportunity  Is there an unmet need this technology addresses?  What is the competitive landscape?  Intellectual Property  “Novel, useful, and non-obvious”  What is the status of your IP?  Research and Development  Key findings to date and future work proposed

12. What sort of projects is QED looking for? So, you have a technology…  Can you imagine one or more products?  Can you imagine one or more groups that need your product? Questions that retire business risk…  Milestone-driven vs. Hypothesis-building  Can they be answered in 12 months and with $200,000? Help with answering these questions…  Your Technology Transfer Office  One of the goals of QED is to provide assistance in answering what is currently unknown 12

13. Please visit our website for complete details  http://www.sciencecenter.org/qed-intro http://www.sciencecenter.org/qed-intro Contact Us  Adam Greenspan – Program Manager (agreenspan@sciencecenter.org)agreenspan@sciencecenter.org  Chris Laing – Vice-President of Science and Technology (claing@sciencecenter.org)claing@sciencecenter.org Further Information 13