2. Hormones and the Endocrine System By Elizabeth Chapman, Alec Smith, and Niki Williams

5. Hormones and the Endocrine System Key Points of Focus: Nervous system relationship Maintenance of homeostasis Types of hormones/effects on vertebrates Effect on invertebrates

6. Review and Overview The Endocrine System is composed of all of the body's hormone secreting cells Hormones are chemical signals carried by the circulatory system that communicate regulatory messages through the body One hormone can elicit a variety different responses from different target cells There are 3 simple hormonal pathways 1.Simple endocrine 2.Simple neurohormone 3.Simple neuroendocrine

7. The Three Simple Pathways

8. Review of Hormonal Signaling Hormonal signaling occurs through the binding of a receptor protein to a target cell: 1.Water-soluble hormones bind to plasma membrane, triggering a signal transduction pathway 2. Lipid-soluble hormones bind to an intracellular receptor (Either the cytoplasm or nucleus), where it acts as a transcription factor

9. Review of Hormone Signaling Water-Soluble Hormone Hormone binds to receptor on plasma membrane Triggers signal transduction pathway; leads to response Lipid-Soluble Hormone Signal-receptor complex acts as a transcription factor Hormone binds to intracellular receptor either in the nucleus (as shown) or the cytoplasm

10. Anterior and Posterior Pituitary anterior pituitary: synthesizes/secretes hormones; four are tropic (regulate function of other endocrine organs) others nontropic growth hormone posterior pituitary: stores/secretes two hormones made by hypothalamus 1.ADH 2.Oxytocin

11. Anterior Posterior Hormones Growth Hormones release insulin-like growth factors which circulate in the blood to stimulate bone/cartilage growth hypersecretion leads to gigantism hyposecretion leads to dwarfism

12. Thyroid Gland Two lobes on trachea Maintain homeostasis (blood pressure, heart rate, muscle tone, and digestion) Affected by iodine in diet

13. Control of Blood Glucose Pancreas: produces bicarbonate ions and digestive enzymes carried to small intestine via pancreatic duct Exocrine: tissues and glands that discharge secretions into ducts Islets of Langerhans: clusters of endocrine cells (in exocrine tissue of pancreas Blood glucose regulated by glucagon and insulin

14. Glucagon Raises Blood Glucose Levels From alpha cells Promotes liver's glycogen breakdown and release of glucose Only liver cells are responsive to glucagon Fat cells convert sugars to fats Skeletal muscles use released glucose for use in exercise

15. COOKIES

16. Insulin Lowers Blood Glucose Levels From beta cells Slows liver's glycogen breakdown Inhibits conversion of amino acids and glycerol to glucose Promotes uptake of glucose by most somatic cells and synthesis and storage

17. Glucose Homeostasis (blood glucose regulation) When blood glucose is too HIGH insulin is released to lower blood sugar concentration When blood glucose is too LOW >glucagon is released to increase blood glucose concentration

18. Diabetes Mellitus Type 1: Insulin Dependent (usually children) Immune system destroys pancreas's beta cells which produce insulin Type 2: Non Insulin Dependent (anyone, yet obese susceptible) deficiency of insulin or reduced responsiveness of target cells from change in insulin receptors

19. Calcium Homeostasis Too much calcium: thyroid gland releases calcitonin which is deposited in bones; reduces kidney absorption Too little calcium: parathyroid glands (on thyroid) release PTH, take calcium from bones, increase absorption from kidneys

21. Adrenal Hormones: Response to Stress Adrenal Cortex: (outer) -made of true endocrine cells Adrenal Medulla: (center) made of secretory cells -secretes catecholamines Catecholamines: act directly on target tissues for a bioenergetic boost

22. Catecholamines: Epinephrine and Norepinephrine Positive or negative stress: catecholamines released by adrenal medulla Epinephrine(adrenaline)- heart and metabolic rates Norepinephrine(noradrenaline) - sustains blood pressure Functions: -increase rate of liver's glycogen breakdown -promote glucose release by liver cells -stimulate release of fatty acids from fat cells Effects on Respiratory and Cardiovascular System -increased rate of heart beat -dilated bronchiloes in lungs, more oxygen to body -smooth muscles contract, other relax, blood goes to heart brain and skeletal muscles

23. Steroid Hormones from Adrenal Cortex Adrenal cortex: endocrine signals cause hypothalamus to secrete releasing hormone that stimulates anterior pituitary gland to release tropic hormone ACTH, causes release of steroids Corticosteroids: Mineralocortecoids -act on salt/water balance ie:aldosterone stimulates kidney cells to reabsorb salt ions and water, raising blood pressure and volume Glucocortecoids -breakdown of muscle proteins -helps body with longterm environmental changes -anti-inflammatory, supresses immune system -carbon skeletons go to liver and kidneys, converted to glucose, released

24. Gonadal Sex Hormones Androgens: (testosterone) -stimulates development of male reproductive system -can determine gender of fetus -PUBERTY Estrogen:(estradiol) -maintenance of female reproduction system -female secondary sex characteristics Progestins (progesterone) -prepares and maintains uterus

25. Melatonin and Biorhythms Pineal gland: small mass of tissue near center of brain -sometimes has light sensitive cells that control secretory activity -synthesizes and secretes MELATONIN Melatonin regulates light/season changing /day length related functions(ie: reproduction)

26. Invertebrate Regulatory System- Insects Brain Hormone: made by neurosecretory cells in brain -stimulates release of ecdysone Ecdysone: promotes molting and development of adult characteristics Balanced out by: Juvenile Hormone: promotes larval characteristics

27. Overlap of Endocrine and Nervous Systems Specialized nerve cells called neurosecretory cells release hormones into the blood via the extracellular fluid Some chemicals serve as both o hormones in the endocrine system o chemical signals in the nervous system Nervous system plays a role in regulating the secretion of certain endocrine glands in certain sustained responses like the reproductive cycles of many animals

28. Quick Note About Local Regulators Local regulators convey messages between neighboring cells- paracrine signaling Elicit quicker responses than long-distance endocrine signaling by hormones The binding of a local regulator triggers events within the target cell that are similar to those elicited by hormones Includes neurotransmitters, the key local regulators of the nervous system, growth factors, prostaglandins, and nitric oxide

29. Group Activity Get one set of notecards Use notecards to answer questions asked by Alec, Elizabeth, or Niki First person to put up the correct notecard wins a point Group that wins gets a random bag of stuff