2. Viruses Virus – Latin for “toxin or poison” Particles of nucleic acid, protein, and sometimes lipids Enter living cells and use the cell to produce more viruses

3. Are viruses living? To be classified as living one has to: – Be made of cells – Reproduce independently – Have a genetic code – Obtain and use energy – Respond to environment – Change over time Do viruses match these criteria: – No – Yes – No – Yes

4. Viruses Viruses have a core of DNA or RNA surrounded by a protein coat Protein coat is called a capsid – Enables virus to enter host cell Can live outside of a host in a crystallized form

5. Virus Structures: Helical - plant viruses Tobacco Mosaic Virus – infects tobacco plants

6. Virus Structures: Icosohedral (spherical) – animal viruses Influenza virus

7. Virus Structures: Complex T4 Bacteriophage - infect bacteria

8. Virus Structures: Complex Poxvirus (smallpox)

9. Viral Infections Bacteriophages can cause two types of viral infections – Lytic – Virus DNA enters cell, makes new copies of virus, and causes lysis Lysis = cell death, cell bursts open – Lysogenic – virus inserts DNA into DNA of host cell so it can replicate with the host DNA

10. Lytic and Lysogenic Infections

11. Retroviruses Virus RNA is translated into DNA The DNA copy is then inserted into the host cell’s DNA Often remains dormant before directing production of new viruses Causes cell death retro- means “backward”

12. Human Immunodeficiency Virus (HIV) - retrovirus

13. Virus Classification Viruses are classified according to 1. the type of nucleic acid (DNA or RNA) 2. Whether the nucleic acid is single or double stranded 3. Whether the virus has an envelope 4. By the type of infections that occur There are about 1,550 known virus species and about 30,000 known strains

14. Modes of transmission Vertical transmission (mother to child) - the baby is born with the virus. Ex. HIV or Hepatitis B Horizontal transmission (person to person) - most common – Blood exchange, sexual activity, saliva exchange, breathing (aerosol affect), insect vectors, or contaminated food or water

15. Diseases Caused by Viruses Common ColdChicken Pox

16. Diseases Caused by Viruses (cont’d) Herpes SimplexHepatitis B (liver)

17. Diseases Caused by Viruses (cont’d) Polio (paralysis)Ebola (hemorrhage)

18. Vaccinations Help prevent infection Can consist of live or killed viruses Vaccines build up the body’s immune response for when the actual virus enters the body

19. Cow pox vaccination 1749 Acquired immunization Artificial injection of a small amount of virus Body’s immune response makes antibodies