1. Warm-Up / EOC Prep 1. Which statement best distinguishes aerobic from anaerobic respiration? A. Only aerobic respiration involves fermentation. B. Only anaerobic respiration occurs in the mitochondria. C. Only aerobic respiration requires oxygen. D. Only anaerobic respiration produces carbon dioxide. 2. Some organelles have their own DNA that is distinct from the cell’s nuclear DNA. This is true of which organelle? A. cell wall B. mitochondrion C. plasma membraneD. vacuole

2. Warm-Up / EOC Prep 3. List the correct order for the stages of mitosis shown in the diagram. a. B, E, C, D, Ab. C, B, E, A, D c.A, B, C, D, E d. D, C, B, A, E

3. Agenda Warm-up Notes Ch. 40 guided reading WS CC & Mit Biologix Video Cancer Cells Video Clean-up Cool-down

4. PMAT Hand Signals P- plump M- middle A- apart T- two

5. Regulating the Cell Cycle and Cancer

6. Cells have a system of controls, much like how traffic lights control the flow of traffic.

7. The cell cycle has key checkpoints or inspection points. At these checkpoints the cell might receive signals to move on to the next phase (greenlight) or a signal that delays the cell so that it can complete the current stage (yellow/red light). These checkpoints are controlled by PROTEINS.

8. Scientists have discovered a family of closely related proteins, known as cyclins, that are involved in cell cycle regulation. Cyclins regulate the timing of the cell cycle in eukaryotic cells.

9. When the regulation of cell growth and division is lost-CANCER-or the uncontrolled growth of cells-may result

10. Cancer cells do not respond to the signals that regulate the growth of most cells. As a result, they divide uncontrollably and form masses of cells called tumors that can damage surrounding tissues

11. Cancer cells may break loose from tumors and spread throughout the body, disrupting normal activities and causing serious medical problems or even death.

12. Cancer has many causes including smoking tobacco, radiation exposure, pollution, viral infections, and others. However, all cancers have one thing in common: the control over the cell cycle has broken down.

13. 2000 statistics

14. Types of cancer: (these are just some common types-there are many more!) 1. Breast cancer2. Lung cancer 3. Bladder cancer4. Brain cancer 5. Ovarian cancer6. Leukemia (cancer of the blood) 7. Prostate cancer8. Stomach cancer

16. Treatment for cancer: 1. Surgery-attempts to remove the tumor 2. Radiation therapy-uses radiation to damage and kill cancer cells

17. 3. Chemotherapy-drugs that interfere with cell division and target rapidly dividing cells-can harm healthy tissues 4. Immunotherapy-designed to help the body’s own immune system fight the tumor

18. The treatment depends on the location of the tumor and the stage of the cancer. The goal of treatment is the removal of the cancer without damaging the rest of the body.

19. REVIEW

20. Cells have a system of _______________ that regulate the cell cycle.

21. controls

22. The family of proteins involved in cell cycle regulation

23. cyclins

24. The uncontrolled growth of cells is…

25. cancer

26. What are some common types of cancer?

27. Lung, ovarian, stomach, etc…

28. What are possible treatments for cancer?

29. Surgery, immunotherapy, chemotherapy, radiation

30. Use your textbooks to complete the worksheets.

31. Cool-Down 1. What proteins regulate the cell cycle? 2. What happens when cells do not respond to the signals that normally regulate their growth? 3. Why can cancer be considered a disease of the cell cycle?