2. PSYC 2920 Lecture 8

3. Dependence, Addiction and the Self-Administration of Drugs Factors that Alter the Reinforcing Value of Drugs Other Deprivations and Motivations Other Deprivations and MotivationsHunger Previous Experience with Other Drugs Previous Experience with Other Drugs Previous Experience with the Same Drug Previous Experience with the Same Drug Physical Dependence Physical Dependence Priming Priming Conditioned Reinforcement Conditioned Reinforcement Second-Order Schedules Second-Order Schedules Conditional tolerance drug seeking vs. taking have dissociable mechanisms

4. Dependence, Addiction and the Self-Administration of Drugs The Neuroanatomy of Motivation and Reinforcement Olds and Milner (1954) Experiment Olds and Milner (1954) Experiment Reinforcement Centers Motivation Control System of the Brain Motivation Control System of the Brain Ventral tegmental area (VTA) Nucleus accumbens Mesolimbic dopamine system Basal ganglia Motor loop Thalamus > cortex > amygdala > hippocampus Learning and memory system Incentive salience

5. Dependence, Addiction and the Self-Administration of Drugs Motivation Control System of the Brain

6. Reward circuitry

7. Reward circuitry continued

8. Dependence, Addiction and the Self-Administration of Drugs The Neuroanatomy of Motivation and Reinforcement “Wanting” Versus “Liking” in Reinforcement “Wanting” Versus “Liking” in Reinforcement “Pleasure Centers” Reinforcing Effects of Drugs Reinforcing Effects of Drugs Stress and Reinforcement Stress and Reinforcement Stress, both present and in the past, increases the strength for reinforcing stimulus.

9. Dependence, Addiction and the Self-Administration of Drugs What Happens During Addiction? Addiction Addiction Drugs alter the functioning of the motivation system and the behavior. How?Theory

10. Dependence, Addiction and the Self-Administration of Drugs Incentive Sensitization Theory Drug Craving Drug Craving The desire to experience the effect(s) of a previously experienced psychoactive substance. Robinson & Berridge Motivational aspect (“wanting”) is sensitized while (“liking”) shows tolerance Motivational aspect (“wanting”) is sensitized while (“liking”) shows tolerance Provides a good explanation strong craving in the absence of dysphoric withdrawal. Provides a good explanation strong craving in the absence of dysphoric withdrawal. Provides an explanation for impulsivity Provides an explanation for impulsivity

11. Dependence, Addiction and the Self-Administration of Drugs Hedonic Dysregulation and Adaptation Based on physical dependence model Based on physical dependence model Allostatic process Allostatic process Repeated use and/or cessation of use leads to dysphoria, anxiety, depression Set points change if drug use is persistent Hedonic dysregulation Hedonic dysregulationDysphoria Psychological withdrawal

12. Comparing incentive sensitization to Hedonic dysregulation (aka allostasis model) Incentive sensitization Incentive sensitization impulsivity impulsivity pure “psychological” addiction pure “psychological” addiction cue-associated relapse cue-associated relapse Positive reinforcement model Positive reinforcement model Hedonic dysregulation Transition from impuslivity to compulsivity Transition from impuslivity to compulsivity Focus on withdrawal Focus on withdrawal Stress-related relapse Stress-related relapse Negative reinforcement model Negative reinforcement model

13. Dependence, Addiction and the Self-Administration of Drugs Behavioral Economics: Choosing to Use Drugs Based on behavioral mechanisms of positive reinforcement Based on behavioral mechanisms of positive reinforcement Making choices Making choices The Matching Law The Matching Law Animals distribute their resources (time, money, and effort) to different responses in proportion to the density of reinforcement provided by the response. Spiral to Addiction Spiral to Addiction Confound for withdrawal-based explanations?

14. Dependence, Addiction and the Self-Administration of Drugs Behavioral Economics: Choosing to Use Drugs Choice and Time Choice and Time Discounting of delay Perceived value of something decreases the further away it is in time Perceived value of something decreases the further away it is in time

15. Dependence, Addiction and the Self-Administration of Drugs Behavioral Economics: Price and Demand Inelastic Inelastic Consumers continue to spend the same amount or more for a drug even though they are not able to purchase as much. Elastic Elastic Consumers start spending less for the drug in response to a price increase.

16. Dependence, Addiction and the Self-Administration of Drugs Behavioral Economics: Price and Demand Demand curves for monkeys responding on FR schedules of 4, 8, 16, 32, 64, and 128 to receive access to a drinking tube that delivered water containing phencyclidine (PCP).Demand curves for monkeys responding on FR schedules of 4, 8, 16, 32, 64, and 128 to receive access to a drinking tube that delivered water containing phencyclidine (PCP).