1. COMORBIDITIES IN PATIENTS WITH IRRITABLE BOWEL SYNDROME Natalia Pritcan Alina Burianov,Gheata Irina Alina Burianov,Gheata Irina Doctor Melania Macarie Doctor Melania Macarie Faculty of Medicine, UMPh Targu Mureş Department of Gastroenterology I, Faculty of Medicine, UMPh Targu Mureş

2. Introduction Irritable bowel syndrome (IBS) is a symptom-based diagnosis characterized by chronic abdominal pain, discomfort, bloating,and alteration of bowel habits. Irritable bowel syndrome (IBS) is a symptom-based diagnosis characterized by chronic abdominal pain, discomfort, bloating,and alteration of bowel habits. As a functional gastrointestinal disorder, IBS has no known organic cause. As a functional gastrointestinal disorder, IBS has no known organic cause. IBS can be classified as either diarrhea-predominant (IBS-D), constipation-predominant (IBS-C), with alternating stool pattern (IBS-A) or pain-predominant. IBS can be classified as either diarrhea-predominant (IBS-D), constipation-predominant (IBS-C), with alternating stool pattern (IBS-A) or pain-predominant.

3. Aim   The aim of this study was to analyze comorbidities, which appear with greater frequency in patients diagnosed with IBS. We took in consideration the following areas: psychiatric disorders other gastrointestinal disorders metabolic disorders cardiovascular disorders

4. Material and method We performed a retrospective study of 2459 patients hospitalized in Gastroenterology Clinic of Targu Mures County Clinical Emergency Hospital between 01.01.2012 -31.12.2013. Almost everything about IBS is totally dependent on the individual patient, therefore this syndrom can be nothing more than a mild discomfort or completely debilitating. Most people can control their symptoms with diet, stress management, and prescribed medications.

5. IBS Pathophysiology

6. Results:

7. During the studied period there were diagnosed 73 (2.9 %) patients with IBS. People with IBS often suffer from other GI and non-GI conditions. All hospitalized patients who have been diagnosed with this syndrom had at least 2 comorbidities of the categories listed above.

8. The average age of patients was 53.4 years, predomining at females (ratio of F/M 2.2 /1).

9. GI conditions such as gastritis, hiatal hernia, hepatic steatosis, disorders of biliary pathway, reflux esophagitis and hepatitis are more common in people with IBS than the general population.

10. Stress, Anxiety,Depression and IBS High prevalence of psychiatric disorders in patients with IBS sugest that the association of IBS and psychiatric disorders may be more fundamental than was previously believed. Stress, Anxiety,Depression and IBS Regardless of whether they have IBS, people with anxiety tend to worry greatly about issues such as health, money, or careers, according to the Anxiety Disorders Association of America. High prevalence of psychiatric disorders in patients with IBS sugest that the association of IBS and psychiatric disorders may be more fundamental than was previously believed.

11. “While there are multiple factors leading to irritable bowel syndrome, there is a strong association with psychological disorders such as anxiety and depression. However, it is not always clear whether the anxiety or depression causes IBS or results from the IBS symptoms.” Dr Wang Yu Tien, Consultant, Department of Gastroenterology and Hepatology, Singapore General Hospital (SGH).

12. Other associated conditions

13. Conclusions: People with IBS frequently have psychiatric disorders, gastritis, hiatal hernia, hepatic steatosis, disorders of biliary pathway and reflux esophagitis. There is a strong link between IBS on one hand, and anxiety and depression on the other. However, it is unclear which one comes first. IBS affects about twice as many women as men. IBS has no direct effect on life expectancy. It is, however, a source of chronic pain, fatigue, and other symptoms and contributes to work absences.

14. Thank you!