1. FOSBE 2009 3 rd Conference on Foundations of Systems Biology in Engineering Denver, Colorado Inverness Hotel & Conference Center August 9-12, 2009 www.fosbe.org

2. Organization Conference chair Conference chair Mike Henson, Department of Chemical Engineering, UMass Mike Henson, Department of Chemical Engineering, UMass Conference co-chairs Conference co-chairs David de Graaf, Vice-President of Biotherapeutics and Integrative Biology, Boehringer-Ingelheim David de Graaf, Vice-President of Biotherapeutics and Integrative Biology, Boehringer-Ingelheim Hiroaki Kitano, Director of Sony Computer Science Laboratories, Japan Hiroaki Kitano, Director of Sony Computer Science Laboratories, Japan Linda Petzold, Department of Computer Science, UCSB Linda Petzold, Department of Computer Science, UCSB Hans Westerhoff, Professor of Systems Biology, The University of Manchester, United Kingdom Hans Westerhoff, Professor of Systems Biology, The University of Manchester, United Kingdom Facilitators Facilitators Kathryn Jurgensen & Robin Craven Kathryn Jurgensen & Robin Craven International Program Committee International Program Committee

3. Technical Program & Sponsors SundayMondayTuesdayWednesday Morning Training Workshop Drug Development Network Modeling Circadian Systems Afternoon Training Workshop Free time Federal Funding Roundtable Free time EveningReception Alternative Fuels Education Synthetic Biology NightKeynote Poster Session I Poster Session II Award Ceremony & Banquet

4. Invited Speakers Erin O’Shea, Harvard (Keynote) Erin O’Shea, Harvard (Keynote) Adam Arkin, UC-Berkeley Adam Arkin, UC-Berkeley David Balaban, Amgen David Balaban, Amgen Bill Bentley, U. Maryland Bill Bentley, U. Maryland Frank Doyle, UC-Santa Barbara Frank Doyle, UC-Santa Barbara Dan Gillespie, Gillespie Consulting Dan Gillespie, Gillespie Consulting Albert Goldbeter, U. Brussels, Belgium Albert Goldbeter, U. Brussels, Belgium Bruce Gomes, Pfizer Bruce Gomes, Pfizer Vassily Hatzimanikatis, EPFL, Switzerland Vassily Hatzimanikatis, EPFL, Switzerland Erik Herzog, Washington U. Erik Herzog, Washington U. Ravi Iyengar, Mount Sinai Medical School Iya Khalil, Gene Network Sciences Art Lander, UC-Irvine Doug Lauffenburger, MIT Jim Liao, UC-Los Angeles Jens Nielsen, Chalmers U. Technology, Sweden Bodo Stern, Harvard Masaru Tomita, Keio U., Japan Hiroki Ueda, Kyushu U., Japan Eberhard Voit, Georgia Tech Huimin Zhao, U. Illinois

5. Student Training Workshop Sunday, August 9, 9:00 am - 5:00 pm Mathematical Modeling Methodology at Amgen (David Balaban, Amgen) Mathematical Modeling Methodology at Amgen (David Balaban, Amgen) Network Robustness (Frank Doyle, UCSB ) Network Robustness (Frank Doyle, UCSB ) An Example of How Systems Biology is Contributing to Drug Discovery in the Pharmaceutical Setting (Bruce Gomes, Pfizer) An Example of How Systems Biology is Contributing to Drug Discovery in the Pharmaceutical Setting (Bruce Gomes, Pfizer) Bioenergetics and Biochemical Network Thermodynamics (Vassily Hatzimanikatis, EPFL) Bioenergetics and Biochemical Network Thermodynamics (Vassily Hatzimanikatis, EPFL) Circadian Entrainment and Rhythm Generation (Erik Herzog, Washington U and Hiroki Ueda, Kyushu U) Circadian Entrainment and Rhythm Generation (Erik Herzog, Washington U and Hiroki Ueda, Kyushu U) Stochastic Chemical Kinetics (Dam Gillespie, Gillespie Consulting) Stochastic Chemical Kinetics (Dam Gillespie, Gillespie Consulting) Parameter Estimation and Structure Identification in Metabolic Networks (Eberhard Voit, Georgia Tech) Parameter Estimation and Structure Identification in Metabolic Networks (Eberhard Voit, Georgia Tech)

6. FOSBE Founders Award Established to recognize exceptional contributions to the systems biology field Established to recognize exceptional contributions to the systems biology field Award winner was selected by a committee comprised of the five conference co-chairs of FOSBE 2009 and the two chairs of the previous FOSBE meetings Award winner was selected by a committee comprised of the five conference co-chairs of FOSBE 2009 and the two chairs of the previous FOSBE meetings Prof. Doug Lauffenburger (MIT) was selected as the first award winner Prof. Doug Lauffenburger (MIT) was selected as the first award winner Prof. Lauffenburger will be honored at the banquet the final night of FOSBE 2009 Prof. Lauffenburger will be honored at the banquet the final night of FOSBE 2009

7. Inverness Hotel

8. Sponsors NSF - $15K NSF - $15K ARO - $10K ARO - $10K ICB - $9K ICB - $9K Amgen - $5K Amgen - $5K AztraZeneca - $5K AztraZeneca - $5K Boehringer-Ingelheim - $5K Boehringer-Ingelheim - $5K Entelos - $5K Entelos - $5K Pfizer - $2K Pfizer - $2K Total - $56K Total - $56K

9. Budget Summary Income Income 98 registrants 98 registrants $56K in sponsorship $56K in sponsorship $20K in expected CACHE revenue $20K in expected CACHE revenue Unexpected expenses Unexpected expenses $30K food & beverage requirement $30K food & beverage requirement $83K hotel room commitment $83K hotel room commitment Estimated $25K loss from hotel Estimated $25K loss from hotel Conference expected to lose about $5K Conference expected to lose about $5K