1. Course of Immunology - introduction (2015/2016) Marta Sobotková email: marta.sobotkova@fnmotol.cz@fnmotol.cz

2. Course structure ● Lectures -Presence in lectures is obligatory -Lectures are held every Tuesday at 8:00-9:40 - Three absences are tolerated, more frequent absences must be based on official certificate and will be solved individually

3. DateThemeTeacher 6.10. 2014Immune system, overview. Phagocytic cells, complement. Communication between cells of immune systems, adhesion molecules, cytokines. prof. Špíšek 13.10. 2014Antigen processing and presentation, HLA I and II class.prof. Šedivá 20.10. 2014Specific (adaptive) immunity T and B lymphocytesPharmDr.Palich - Fučíková 27.10. 2014Immunity against infectionAdkins 3.11. 2014Immunodeficiency, vaccinationprof.Šedivá 10.11. 2014Immunity against tumors.prof. Špíšek 24.11. 2014Immunology of transplatationdr. Kalina 1.12. 2014Autoimmunity. Immunopathology.dr. Sobotková 8.12. 2014Immunopathological reactions, allergydr. Kayserová 15.12. 2014Immunotherapydr. Podrazil 5.1. 2015Clinical aspects of immune disordersDr. Horváth

4. ● Seminars - The first seminar and presentation of your thesis are compulsory; the time of other seminars is devoted to self-studying, preparation of seminar thesis and consultations with teachers Course structure

5. Seminar thesis ● groups of 1-3 students ● structure of thesis: -1000 – 2000 words -form of an essay -briefly & concisely & interestingly -Abstract, text and references (literature) are obligatory, subchapters and discussion are recommended ●Term of submission: until 30.10.2015 -in the digital form (doc form preffered) - has to be sent to: irena.novakova@lfmotol.cuni.czirena.novakova@lfmotol.cuni.cz

6. Regulatory T cells - function and subtypes IL-17, its role in pathologic inflammatory process Immune homeostasis in the gut and oral tollerance Biology of NKT cells Toll-like receptors and its function The role of B lymphocytes and antibodies in antitumor immunity Immunology of sepsis Immunology of coeliac disease. Pathogenesis of oedema in hereditary angioedema and targets for acute attack treatment Mechanisms of dysregulation in humoral immunodeficiences – CVID as model disease Presence and future od monoclonal antibodies in allergic diseases treatment The newest strategies of cancer immunotherapy. Seminar thesis

7. - November 18 and 25, time 8.00-9.40 am. - each thesis will be presented verbally - range: 8 minutes - Powerpoint presentation (6-10 slides) Oral presentations

8. Final appraisal ● Presence on lectures ● Seminar thesis: fulfilled / not fulfilled + verbal appraisal (after presentation) ● Verbal examination: 2 out of 50 questions

9. Evaluation of the essay: 1/ Adherence to the length limits 2/ Correct content of the essay, no serious misunderstandings 3/ Satisfactory graphical layout and style of the essay Other comments: Evaluation of the verbal presentation: 1/ Adherence to the length limits 2/ Correct content of the essay, no serious misunderstandings 3/ Satisfactory graphical layout and style of the presentation

10. http://imunologie.lf2.cuni.cz/ ● shedules ● presentations (download possible) ● recommended literature, links ● contacts

11. Citation Literature / References: 2.DRISCOLL DA, SALVIN J, SELLINGER B, et al. Prevalence of 22q11 microdeletions in DiGeorge and velocardiofacial syndromes: implications for genetic counselling and prenatal diagnosis. J Med Genet 1993: 30: 813-7. 3.SEDIVA A, BARTUNKOVA J, ZACHOVA R, et al. Early development of immunity in diGeorge syndrome. Med Sci Monit 2005: 11: 182-7. „Most of the patients are hemizygous for 22q11.2, some have defects in various loci on chromosome 10, about 10% of cases are familial (2, 3)„

12. Sources Bibliographic databases Clinical sources online

13. Pubmed – www.pubmed.com

14. Medscape - www.emedicine.com

15. Up-to-date – www.uptodate.com

16. Orphanet – www.orpha.net

17. Good luck with Your essays and presentations !