1. MedAustron Dr. Peter Urschütz, EBG MedAustron GmbH

2. The MedAustron facility
CAS - Accelerators for Medical Applications

3. CAS - Accelerators for Medical Applications
Construction of MedAustron
Construction period of 1 ½ years: March 2011 – Sept 2012
CAS - Accelerators for Medical Applications

4. CAS - Accelerators for Medical Applications
Construction of MedAustron
CAS - Accelerators for Medical Applications

5. CAS - Accelerators for Medical Applications
Accelerator installation
Accelerator installation: Q – still ongoing; Synchrotron installation finished in Q1 2014
Beam commissioning in parallel: Q – still ongoing
CAS - Accelerators for Medical Applications

6. Accelerator Commissioning Status
Proton beams of highest energy in 2 irradiation rooms (horizontal beam lines)
Active beam scanning demonstrated
CAS - Accelerators for Medical Applications

7. CAS - Accelerators for Medical Applications
Beam parameters
Particles
protons, carbon ions
Energy
Clinical energies: p: MeV; C6+: MeV/u -> 3-37 cm penetration depth in water
IR1: clinical energies + up to 800 MeV for protons
Intensity
Per spill: 1 * 1010 (p) / 4 * 108 (C6+)
Size
4-10 mm FWHM [in vacuum]
Scanning field : 20x20 cm2 (IR1-3), 12x20 cm2 (IR4)
+/- 0.5 mm position, 70 m/s scanning
CAS - Accelerators for Medical Applications

8. CAS - Accelerators for Medical Applications
100‘000s different beam
combinations…
Accelerator is able to generate:
2 ion species
255 different energies
4 beam sizes
4 intensities
8 extraction lengths
65’280 Beam combinations per beam line
Gantry: different angles need to be considered
Non-clinical research: extended energy range
huge amount of commissioning work
Big difference to accelerators used for research purposes!
Example for table to select a beam combination
CAS - Accelerators for Medical Applications

9. Ion beam therapy – innovative form of radiotherapy
active energy selection -> penetration depth
transverse pencil beam scanning
online beam monitoring
Courtesy of GSI
CAS - Accelerators for Medical Applications

10. Ion beam therapy – innovative form of radiotherapy
Main benefit: protection of surrounding healthy tissue.
Treatment of tumors next to organs at risk
Huge benefit specially for kids.
CAS - Accelerators for Medical Applications

11. CAS - Accelerators for Medical Applications
Radiotherapy
critical organ: brain stem
critical organ: (optical nerve)
Aim:
Application of high dose in target volume, aiming at killing tumor cells.
Protection of healthy surrounding tissue and organs at risk.
Dose distribution adapted to tumor.
Types of radiation:
Conventional therapy: photons, electrons
Ion therapy: protons, light ions
tumor
Courtesy GSI
CAS - Accelerators for Medical Applications

12. Comparison of photons and protons: skull base tumor
CAS - Accelerators for Medical Applications

13. Patient treatment needs much more…
Bring beam to the patient
Bring patient to the beam
Treatment table
Robotic system
Patient position verification system
Immobilization devices
Oncology information system
Treatment planning system
Imaging devices (MRI, CT, PET)
CAS - Accelerators for Medical Applications

14. Ion beam therapy -> technologies & vendors
Different accelerators and beam delivery technologies:
Synchrotrons (protons, ions) vs. cyclotrons (protons)
Double scattering vs. pencil beam scanning
Commercial vendors on the market (offering turn key solutions):
Cyclotrons: a.o. IBA, VARIAN, MEVION, PRONOVA, SUMITOMO,…
Synchrotrons: HITACHI, MITSUBISHI, TOSHIBA
CAS - Accelerators for Medical Applications

15. Ion beam therapy -> large market
COUNTRY
WHO, WHERE
PARTICLE
S/C/SC* MAX. ENERGY (MeV)
BEAM DIRECTIONS
START OF TREATMENT
TOTAL PATIENTS TREATED
DATE OF TOTAL
Canada
TRIUMF, Vancouver p
C 72
1 horiz.
1995
182
Dec-14
Czech Republic
PTC Czech r.s.o., Prague
C 230
3 gantries, 1 horiz.
2012
357
China
WPTC, Wanjie, Zi-Bo
2 gantries, 1 horiz.
2004
1078
IMP-CAS, Lanzhou
C-ion
S 400/u
2006
213
SPHIC, Shanghai
S 250
3 horiz.
2014 13
S 430/u 22
England
Clatterbridge
C 62
1989
2626
France
CAL, Nice
C165
1991
5205
CPO, Orsay
1 gantry, 2 horiz.
7004
Germany
HZB, Berlin
C 250
1998
2525
RPTC, Munich
4 gantries, 1 horiz.
2009
2307
HIT, Heidelberg
2 horiz., 1 gantry**
2009, 2012
824
1723
WPE, Essen
4 gantries***, 1 horiz.
2013
139
PTC, Uniklinikum Dresden
1 gantry
first patient
Italy
INFN-LNS, Catania
C 60
2002
350
CNAO, Pavia
3 horiz., 1 vertical
2011
111
S 480/u
318
APSS, Trento 5
Japan
HIMAC, Chiba
S 800/u
horiz.***, vertical***
1994
8841
NCC, Kashiwa
C 235
2 gantries***
1560
HIBMC, Hyogo
S 230
2001
4652
HIBMC,Hyogo
S 320/u
horiz.,vertical
2146
PMRC 2, Tsukuba
2 gantries
3416
Shizuoka Cancer Center
S 235
2003
1757
STPTC, Koriyama-City
2008
2797
GHMC, Gunma
2010
1486
MPTRC, Ibusuki
3 gantries
1317
Fukui Prefectural Hospital PTC, Fukui City
428
Dec-13
Nagoya PTC, Nagoya City, Aichi
627
SAGA-HIMAT, Tosu
3 horiz., vertical, 45 deg.
547
Aizawa Hospital PTC, Nagano
Oct-14
Poland
IFJ PAN, Krakow 85
Russia
ITEP, Moscow
1969
4368
St.Petersburg
S 1000
1975
1386
Dec-12
JINR 2, Dubna
C 200****
1999
1069
South Africa
NRF - iThemba Labs
C 200
1993
524
South Korea
NCC, IIsan
2007
1496
Sweden
Svedberg Lab.,Uppsala
1431
Switzerland
CPT, PSI, Villigen
2 gantries*****, 1 horiz.
1984, 1996, 2013
7364
USA, CA.
J. Slater PTC, Loma Linda
1990
18362
UCSF, San Francisco
1729
USA, MA.
MGH Francis H. Burr PTC, Boston
2 gantries***, 1 horiz.
8107
Sep-14
USA, IN.
IU Health PTC, Bloomington
2200
USA, TX.
MD Anderson Cancer Center, Houston
3 gantries***, 1 horiz.
5838
USA, FL.
UFPTI, Jacksonville
5376
USA, OK.
ProCure PTC, Oklahoma City
1 gantry, 1 horiz, 2 horiz/60 deg.
1690
USA, PA.
Roberts PTC,UPenn, Philadelphia
2522
USA, IL.
Chicago Proton Center, Warrenville
1782
USA, VA.
HUPTI, Hampton
1200
USA, NY.
ProCure Proton Therapy Center, New Jersey
4 gantries
1168
USA, WA.
SCCA ProCure Proton Therapy Center, Seattle
420
USA, MO.
S. Lee Kling PTC, Barnes Jewish Hospital, St. Louis
SC 250
149
USA, TN.
Provision Center for Proton Therapy, Knoxville
100
Aug-14
Scripps Proton Therapy Center, San Diego
3 gantries, 2 horiz.
220
USA, LA.
Willis Knighton Proton Therapy Cancer Center, Shreveport 28
Ackermann Cancer Center, Jacksonville
2015 1
Apr-15
Large market:
P-facilities: 45
C – facilities: 4
P & C: 4 (Europe: HIT, CNAO;
Japan: HIBMC, China: Shanghai)
+ 8 facilities since beginning of 2014!
Growing market:
Under construction: 32 facilities
(2 p&C: MedAustron, KIRAMS)
ION BEAM THERAPY:
High technology in a multi-disciplinary environment aiming to cure cancer patients.
CAS - Accelerators for Medical Applications

16. Thank you for your attention.
MedAustron is looking forward to welcome you next week at our facility!
Thank you for your attention.
CAS - Accelerators for Medical Applications