1. Chapter 10: Non-narcotic Anti-Inflammatory Analgesics Presented by: Katie and Steffani

2. NSAID:  Nonsteroidal anti-inflammatory drug  It is a peripherally acting, anti-inflammatory analgesics.

3. Various Actions of Asprin:  Anti-inflammatory  Antipyretic  Analgesic  Anticoagulant

4. Therapeutic Uses and Clinical Problems:  Reducing Fever  Reducing Pain  Reducing inflammation  Reducing Clotting  Anticoagulation action might prevent problems if a person needs to clot and they are chemically restricted by the aspirin.

5. COX Inhibitor:  A chemical which inhibits the enzyme cyclooxygenase which converts a precursor substance to prostaglandins that cause inflammation.

6. # ONE & # TWO:  COX – 1 functions primarily to mediate the production of prostaglandins that protect and regulate all functions in the GI tract and regulated blood platelets to initiate clotting.  COX – 2 produce prostaglandins that mediate pain and inflammation.

7. Good and Bad  of the Anticoagulant Action of Aspirin:  Good - reduces hemostasis so is indicated in the treatment of Coronary Artery Disease (CAD) and is used to reduce risk of Cerebral Vascular Accident (CVA: Stroke).  Bad  - causes symptoms ranging from dyspepsia to GI bleeds

8.  Theoretical advantages of COX-2 inhibitors over NSAIDs (non-selective COX-inhibitors) are decreased GI toxicity and platelet blockage.

9.  Correlation between COX enzyme and tumorigenesis: COX enzyme has a role in exciting tumor cell growth because it is over expressed in malignant adenomatous polyps and colon cancer.  Benefits of COX inhibitors: have preliminarily shown efficacy in treating skin and colon cancer.