1. Gilead -Topics in Human Pathophysiology Fall 2009 Drug Safety and Public Health

3. Blood Consists of: – Plasma – Erythrocytes – Leukocytes – platelets– thrombocytes

4. Figure 7.2

5. Blood Consists of: – Plasma: water, ions, nutrients, gases, wastes, proteins. Proteins in plasma: albumin, transport for fats, antibodies, clotting factors – Red Blood Cells – erythrocytes Contain hemoglobin to carry oxygen

6. Blood Components

8. Figure 7.4

9. Tests for Anemia Complete Blood Count (CBC) – Hematocrit – Erythrocyte Count – Hemoglobin concentration – WBC count and differential – Platelet count – Corpuscle characteristics (MCV, MCH) – Etc.

10. Blood Consists of: – White blood cells – leukocytes Protect against pathogens by: – causing inflammation and fever – phagocytosing pathogens – creating antibodies to tag pathogens for destruction – killing pathogens in other ways – Creating a cadre of cells to fight reinfection by specific pathogens (immune memory)

11. Blood Components

12. Blood Consists of: – platelets– thrombocytes Aid in blood clotting by: – attaching to injured vessel – Releasing chemicals that attract more platelets Other clotting proteins in the blood finish the clot by a series of chemical reactions that creates protein strands that bind to the site and strengthen the clot.

13. Figure 7.8

14. Blood Production and Disorders Overview of blood production Disorders of erythrocytes Disorders of platelets Disorders of leukocytes

15. Blood Cell Production Occurs in bone marrow Also called hemopoiesis (hematopoiesis) Stem cells are rapidly dividing Requires iron, Vitamin B 12 (and other B vitamins), other trace minerals, vitamins Controlled by chemical messengers Has 5 lines of production

16. Blood Cell Formation Slide 13 Stem cells are located in red bone marrow Stem cells multiply and become specialized Mature blood cells Erythroblast Myeloblast Nucleus lost Stem cell Monoblast Lymphoblast MegakaryoblastMegakaryocytePlatelets Lymphocyte Monocyte Basophil Eosinophil Neutrophil Granular leukocytes Agranular leukocytes White blood cells Erythrocyte (red blood cell)

17. Blood Disorders Anemias Thrombocytopenia Leukocytopenia, leukocytosis Clotting factor disorders Lipid disorders

18. Structure and function Ischemic Heart Disease Lexiscan, Ranexa Heart Failure Heart and Disease

21. Figure 8.7b

22. Cardiac Cycle http://www.youtube.com/watch?v=D3ZDJgFD dk0&feature=rec-HM-rn http://www.youtube.com/watch?v=D3ZDJgFD dk0&feature=rec-HM-rn