1. GRACE ORDUNG Polycythemia

2. What is Polycythemia? Abnormal increase in blood cells  Red, white and platelets Classified as a cancer Acquired not heredity Defect in gene JAK2 V617F

3. Symptoms, Complications and Risk Factors Itching, headache, dizziness, weakness, sweating, breathing problems, enlarged spleen, numbness, etc. Stroke, heart problems Increases with age, men more than women

4. Normal vs. Polycythemia Normal Hb  Male: 13.5-17.5 g/dL  Female: 12.0-15.5 g/dL Hematocrit  Male: 38.8-50.0%  Female 34.9-44.5 % WBC: 3,500-10,500 cells/uL Platelets: 150-450,000 platelets/uL PV Hb  Male: > 18.5 g/dL  Female: > 16.5 g/dL WBC: > 12,000 cells/uL Platelets: > 400,000 platelets/ uL

5. JAK2 V617F Gene Cause of defect unknown China Japan Union Hospital, Changchun, China  3935 donors Copenhagen City Heart Study  10,507 donors

6. Treatments Phlebotomies Asprinin, hydroxyurea, Interferon A Antihistamines Lifestyle changes

7. References http:// www.nlm.nih.gov/medlineplus/ency/article/000589.htm http:// www.nlm.nih.gov/medlineplus/ency/article/000589.htm http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046277/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1785080/ http://www.cancer.gov/cancertopics/types/myeloproliferative http://www.mayoclinic.org/diseases-conditions/polycythemia-vera/basics/complications/con- 20031013 http://www.mayoclinic.org/diseases-conditions/polycythemia-vera/basics/complications/con- 20031013 http://www.cancer.org/treatment/treatmentsandsideeffects/guidetocancerdrugs/hydroxyurea http://ajcp.ascpjournals.org/content/133/6/942/F1.expansion.html http://www.cancer.gov/cancertopics/pdq/treatment/myeloproliferative/HealthProfessional/page3 http://www.mayoclinic.org/tests-procedures/complete-blood-count/basics/results/prc-20014088 http://www.nlm.nih.gov/medlineplus/ency/article/003683.htm