1. Plasma cell disorders Dr. hassanali vahedian ardakani Medical oncologist hematologist 2013

2. differential diagnosis:  monoclonal gammopathy of undetermined significance (MGUS),  smoldering multiple myeloma (SMM)  Multiple myeloma  Waldenstrom macroglobulinemia,  solitary plasmacytoma,  primary amyloidosis (AL),  POEMS syndrome

6. Lab.test:  Complete blood count  Serum calcium and  creatinine  Serum protein electrophoresis and immunofixation  Urine protein electrophoresis and immunofixation  Serum free light chain  Quantitation of immunoglobulins  bone survey

22. diagnostic criteria for AL amyloidosis require the presence of all of the :following four criteria  Presence of an amyloid-related systemic syndrome (eg, renal, liver, heart, gastrointestinal tract or peripheral nerve involvement)  Positive amyloid staining by Congo red in any tissue (eg, fat aspirate, bone marrow or organ biopsy)  Evidence that the amyloid is light chain-related established by direct examination of the amyloid (eg, immunohistochemical staining, direct sequencing)  Evidence of a monoclonal plasma cell proliferative disorder (eg, presence of a serum or urine M protein, abnormal free light chain ratio, or clonal plasma cells in the bone marrow)