1. Imunoglobulins – structure and function Production of immunoglobulins Genetic determination of immunoglobulin production Clonal selection theory

2. Antigen and epitope

7. Molecule of IgG

8. Hypervaribale region of immunoglobulin molecule binds epitope of the antigen

9. Variable region of immunoglobulin molecule

12. Isotype switching

13. Clonal selection theory

14. Downloaded from: StudentConsult (on 18 July 2006 11:29 AM) © 2005 Elsevier Activation and differentiation of B-lymphocytes

15. Downloaded from: StudentConsult (on 18 July 2006 11:29 AM) © 2005 Elsevier

16. Isotype The class or subclass of an immunoglobulin. Antigenic determinats are on constant part of immunoglobulin molecule.

17. Idiotype An antigenic determinant on the variable region of a specific antibody.

18. Interaction Idiotype-antiidiotype Shoenfeld Y: Nature Medicine 10, 17 - 18 (2004)

19. www.immunology.klimov.tom.ru/1-1.phpwww.immunology.klimov.tom.ru/1-1.php.

20. IgG

22. Primary and secondary immune response gsbs.utmb.edu/microbook/ch001c.htm

23. Downloaded from: StudentConsult (on 18 July 2006 11:29 AM) © 2005 Elsevier

24. IgM on B-cell membrane

25. Expression of surface immunoglobulins on B-cells

27. Downloaded from: StudentConsult (on 20 July 2006 11:29 AM) © 2005 Elsevier Formation of Secretory IgA

28. Affinity: The strength of the binding between a single site of an antibody (one variable region) and an epitope. Avidity: The overall strength of interaction between and antibody and antigen. The avidity depends on affinity and the valency of interactions.

29. Antibody affinity http://pathmicro.med.sc.edu/mayer/rx-2.jpg

30. Antibody affinity

31. Antibody Avidity

32. Biological functions of immunoglobulin molecules Activation of complement system (IgG, IgM) Opsonization (particularly IgG) Neutralization of antigens (IgG, IgA, IgM) Adherence interference (IgA, IgG) Antibody dependent cellular cytotoxicity (ADCC) Agglutation, precipitation (IgG, IgM) Mast cells degranulation (IgE) Transport through placenta (IgG) Imunoregulation (mainly IgG)

33. Antibody dependent cellular cytotoxicity (ADCC) http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/humoral/5classes/u3fg33a.html