1. iChemExplorer iChemExplorer ™ Chemistry Screening Tools

2. iChemExplorer Slide 2 iChemExplorer for your Chemistry Automate the work so I can gather more data Organize the data so I can better understand it iChemExplorer to automate work and organize data in the chem lab

3. iChemExplorer Slide 3 iChemExplorer Tool Set Hardware to Heat and Stir vials in the HPLC autosampler Software to Visualize results

4. iChemExplorer Slide 4 When You Need iChemExplorer Current Applications Design of Experiments Reaction Monitoring Solubility Screening Solvent Selection Stability Testing Catalyst Screening

5. iChemExplorer Slide 5 iChemExplorer = Fast Turnaround Five runs in the time of one run Experiment Cycle Prep> Run/Sample> Analyze> Data> Present

6. iChemExplorer Slide 6 Peak Profile to See Results Follow changes from one sample to the next in Real Time

7. iChemExplorer Slide 7 Example as Effective Process Tool A + B -> C C + B -> D Desired reaction Overdose forms dimer NOTE Dosing and Sampling done overnight with ICE on HPLC “Save the batch!” +0.25eq +0.25eq. Starting Material Product Dimer 0.25eq. = 2.5ul; addition by HPLC autosampler 0.75 eq. optimum This Peak Profile used as evidence

8. iChemExplorer Slide 8 Extend the Value of the HPLC Heat and stir in the HPLC autosampler Same footprint to save space Same PC that runs HPLC software Use HPLC as before – same specs, service and parts

9. iChemExplorer Slide 9 It All Happens in a Sealed Vial Save precious starting materials Near-constant concentration through sampling Vial with crimp top seals solvents and gases inside for extended periods 2 ml and 6 ml vials sizes

10. iChemExplorer Slide 10 Walk-up Chemistry “Fill in the blanks” to create serial sampling sequences with current methods “Set it and forget it” temperature and stir speed control Data presentation as acquired in real-time

11. iChemExplorer Slide 11 iChemExplorer User Interface iSample tab Fill in the blanks to create sampling sequence iHeat tab Manual and automatic control of temperature iGraph tab Create and customize Peak Profiles; paste to other applications; Export in MS Excel

12. iChemExplorer Slide 12 Visualize Analytical Results Traffic Light Plot With Peak Profile and Chromatograph

13. iChemExplorer Slide 13 Copy & Paste Copy and Paste to any Windows application such as Microsoft® Office and enotebooks

14. iChemExplorer Slide 14 Export to Excel One-button export of peak profiles, chromatographs and numerical data

15. iChemExplorer Slide 15 iChemExplorer Product Line ICE System includes Heated Tray, ICEbox and 3-year ICE on-line software license ICE software license available for off-line data analysis 2009 - ICE software compatible with Waters Empower software 2009 – FlowTray plumbed to circulator for sub ambient temps and faster cooling

16. iChemExplorer Slide 16 Support And Service On-site installation and training Support tailored to user needs Service packages available for on- site support Access to experienced user group Don’t forget your ChemGlass account manager

17. iChemExplorer Slide 17 Additional Information Contact your local Chemglass Account Manager Check out the latest products by Chemglass