1. Introducing Freshmen to Drug Delivery Stephanie Farrell and Robert P. Hesketh Chemical Engineering Rowan University ASEE Annual Conference, June 2000

2. Drug Delivery l Exciting multidisciplinary field Medicine, pharmaceutical sciences, chemistry, chemical engineering l What role do chemical engineers play?

3. Introduction This experiment was used in l Freshman Clinic Required of all freshmen 1 3-week module in each discipline Common thread: measurements l Graduate / Senior Elective Apply concepts of drug delivery and model development

4. Overview l Introduction to drug formulations l Experiment l Measurements l Data analysis

5. Drug Delivery l Rate l Duration l Location, location, location

6. Rate and Duration of Release l Contac  12 hr cold capsules membrane system l oral osmotic

7. Location Location Location l Enteric-coated aspirin Stomach pH 2 HCl Intestine pH 8 NaOH

8. Lozenge Formulations l Topical anaesthetics l Pain relief l Antifungal agents l CNS depressants l Sore throat l Cancer l Aids l Depression l Parkinsonism

9. Experiment Cherry Cough Drop t=0 Menthol (7.6 mg) + red dye M d mass of dissolved drug M 0 initial mass 7.6 mg M mass remaining

10. Measurement Spectrophotometer Samples Concentration

11. Data Analysis l Model: M 0 =7.6 mg M d from measurement Need to determine 

12. Does It Make Sense? l What does the model tell us? M d (t = 0) = 0 M d (t =  ) = M 0 = 7.6 mg

13. Parameter Evaluation l Linear form l Plot with Excel l Use Trendline l Slope = 

14. Data Representation l Use model to calculate M d l Compare with Experimental Data

15. Conclusion l Introduction to drug delivery l Chemical engineering principles l Simple, visual experiment l Concentration measurement l Excel, data analysis, parameter evaluation l Compare data with model

16. Feedback “I enjoyed last night's class immensely. It was a practical approach to tying in many of the concepts we've been learning, with a twist of fun. Cool.” –James Downing, MSE candidate