1. #HASummit14 Session #34: Precision Medicine and Embracing Variability David A. Fenstermacher, PhD Chief Research Information Officer, Professor of Biomedical Informatics, Virginia Commonwealth University Samir Courdy, MBA Chief Research Information Officer, Director of Research Informatics at the Huntsman Cancer Institute, University of Utah Facilitator: Eric Just Vice President of Technology, Health Catalyst Samuel Volchenboum, MD, PhD Assistant Professor of Pediatrics Director, Center for Research Informatics Associate Chief Research Information Officer University of Chicago Medical Center Shawn Murphy, MD, PhD Medical Director of Research Computing and Informatics, Partners HealthCare

2. #HASummit14 Topic Intro 2 1.In January 2015, President Obama announced $215M as part of the Precision Medicine Initiative (PMI) 2.The PMI seeks to accelerate: Deeper understanding of disease Which will lead to better-targeted treatments Models for incorporating precision medicine into clinical practice 3.This panel will discuss: What is precision medicine? How can it be achieved?

3. #HASummit14 Poll Question #1 3 Based on my current understanding, precision medicine is: a)The future of medicine and achievable in the next 10-15 years. b)The future of medicine and achievable in the next 15-30 years. c)Not a realistic approach to medicine, even in 30 years. d)A new buzzword for something that we’ve been doing for years. e)I don’t know enough about it to form an opinion.

4. #HASummit14 Lessons Learned 4 1.Precision medicine is about more rapidly determining the molecular cause for disease that will allow a finer-grained classification of diseases and alternate treatment paths for these new disease sub- types. 2.Over the last 20 years, bioinformatics has been creating tools and frameworks to understand molecular underpinnings of disease. This data will be leveraged in clinical decision making. 3.Precision medicine is more than just “genomic medicine.” Genetics will play a big role, but many new types of inputs will be involved including more imaging, device data, and proteomics. 4.Precision medicine will require new ways for researchers to partner with care delivery professionals to speed the time of discovery to implementation as clinical practice. 5.The road to precision medicine is fraught with challenges, including regulatory, organizational, and funding, but we should be encouraged by early examples of success.

5. #HASummit14 Analytic Insights A Questions & Answers 5

6. #HASummit14 Choose one thing… 6 Write down one thing will you do differently after hearing this presentation

7. #HASummit14 Thank You 7

8. #HASummit14 8 Session Feedback Survey 1.On a scale of 1-5, how satisfied were you overall with this session? 1)Not at all satisfied 2)Somewhat satisfied 3)Moderately satisfied 4)Very satisfied 5)Extremely satisfied 2.What feedback or suggestions do you have?

9. #HASummit14 Upcoming Speakers 3:20 PM – 4:10 PM 36) Building Creative and Innovative Organizations Ed Catmull, Co-Founder of Pixar, President of Pixar and Walt Disney Animation Studios 4:10 PM – 4:30 PM Final Polls and Summit Winners 4:30 PM – 5:00 PM 37)Closing Remarks Dan Burton, Chief Executive Officer, Health Catalyst 9 Location Grand Ballroom