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Garlic & Health Health Part University of Leipzig.

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Presentation on theme: "Garlic & Health Health Part University of Leipzig."— Presentation transcript:

1 Garlic & Health Health Part University of Leipzig

2 Garlic & Health:Health part - general aim University of Leipzig Main Goal:- Interactive improvement of garlic quality Elucidation of mechanism Analysis of active of action compoundsImproved drug formulation High quality garlic Improvement of garlic Optimal use of garlic plants and growth conditionsfor therapeutic application Main Focus:- Inflammation and cytokine signaling - Atherosclerosis and serum cholesterol - Cancer and biotransformation - Human Intervention Study

3 Garlic & Health: WP5 Cholesterol and cytokines University of Leipzig High Quality Garlic: Inhibition of cholesterol biosynthesis Indirect Mechanism of Inhibition: Aim:Interaction of garlic constituents with cholesterol biosynthesis

4 Garlic & Health: WP5 Cholesterol and cytokines University of Leipzig Challenge for future project research : Plant part:Health part: Definition of growth conditionsAnalysis of responsibel compounds FertilisationElucidation of mechanism of action (Genetic) Modification of plantsImplications for human health Unexpected Result !! Low Quality Garlic: Stimulation of cholesterol biosynthesis !

5 Garlic & Health: WP5 Cholesterol and cytokines University of Leipzig Aim:Interaction of garlic constitutents with vessel wall Inhibition of Matrix Metalloproteinase-2 Production by DADS, AM and SAC in HCA- endothelial cells No influence on adhesion molecules and NF-kB activity

6 Garlic & Health: WP5 Cholesterol and cytokines University of Leipzig Aim:Interaction of garlic constitutents with cytokine production in human blood Garlic extracts influence the liberation of pro- and antiinflammatory cytokines in human blood High quality garlic shows a better biological cytokine profile Cytokine modulation may indirectly affect NF-kB activation

7 Garlic & Health: WP6 Cancer and biotransformation University of Leipzig Aim:Bioavailability of garlic constituents DADS DADSO In vivo AGS SH AM AMS AMSO2 AMSO S glutathione In vitro

8 Garlic & Health: WP6 Cancer and biotransformation University of Leipzig Aim:Protection against genotoxicity by garlic constituents % of DNA alterations 0 20 40 60 80 100 120 H202H202 5 µM25 µM50 µM100µM Effects of S-allylcystein on H 2 O 2 genotoxicity in HepG2 cells Effects of garlic powders on hepatic UGT activity in rat consuming garlic powders Aim:Modulation of enzymes of carcinogen activation or detoxification 0 50 100 200 Fertilization

9 Garlic & Health: WP7 Pharmaceutics University of Leipzig Aim:- Development of reliable analytical methods - Development of improved pharmaceutical formulation „All purpose“ HPLC method Comparison European Market Products

10 Garlic & Health: WP8 Human Intervention Study University of Leipzig Aim:Placebo-controlled study Run-in periodIntervention period 61319 weeks Blood and urine collection Healthy volunteers with increased risk (mildly hyercholesterolemic) Surrogate markers of atherosclerosis: Plasma lipids (cholesterol, triglycerides, HDL, LDL, lp(a)) Von Willebrand factor Adhesion molecules (VCAM-1, ICAM-1, E-selectine) Surrogate markers of cancer: Phase II enzymes DNA damage

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