1. Instrumenting the Healthcare Enterprise for Discovery Opening Remarks James Mongan, MD President and CEO Partners HealthCare April 11, 2008

2. The Next Frontier in Medicine Partners has focused on providing a system of high quality, safe and efficient care through its High Performance Medicine initiative The next major advance in patient care will be personalized medicine

3. A Vision for Personalized Medicine EMR with clinical decision support Genomic research with high capacity IT Integrated genomic and phenotypic data repository Facilitated translational research leading to Diagnostic discovery Drug development Improved individualized medicine & pre / post symptomatic disease management

4. Clinical and Research Questions u Research –Why do some patients with asthma respond to steroid treatment while others do not? –Why does a mutation in Huntington’s gene cause a lethal defect? –Why do some patients with diabetes have few complications even with “poor” control whereas others with good control have severe complications? u Clinical –Can I lower my cholesterol by diet alone of should I start on an anti-cholesterol drug now? –Will a third line anti-cancer drug be more effective as a first line drug with a patient with lung cancer?

5. A Vision for Personalized Medicine EMR with clinical decision support Genomic research with high capacity IT Integrated genomic and phenotypic data repository Facilitated translational research leading to Diagnostic discovery Drug development Improved individualized medicine & pre / post symptomatic disease management