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“Just a few days... Ebola, Zaire, 1976” Joel Breman, MD, DTPH Fogarty International Center National Institutes of Health 50th Anniversary Celebration Epidemic.

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Presentation on theme: "“Just a few days... Ebola, Zaire, 1976” Joel Breman, MD, DTPH Fogarty International Center National Institutes of Health 50th Anniversary Celebration Epidemic."— Presentation transcript:

1 “Just a few days... Ebola, Zaire, 1976” Joel Breman, MD, DTPH Fogarty International Center National Institutes of Health 50th Anniversary Celebration Epidemic Intelligence Service Centers for Disease Control and Prevention Atlanta, April 22, 2001

2 International Commission for the Investigation and Control of Ebola Hemorrhagic Fever Democratic Republic of the Congo (Zaire), 1976-77 Collaborators Belgium Democratic Republic of the Congo (Zaire) Canada France South Africa United States World Health Organization

3 International Commission for the Investigation and Control of EHF 1976-77 Centers for Disease Control and Prevention Participation In DR Congo (Zaire) Joel Breman, EIS 1976 Stan Foster, EIS, 1962 David Heymann, EIS 1976 Karl Johnson Joe McCormick, EIS 1973 Michael White, EIS 1975 Laboratory, CDC Luanne Elliot Jim Lange Fred Murphy Pat Webb Herta Wulff Task Force Backup, Atlanta John Bryan, EIS 1968 Lyle Conrad, EIS 1965 Bill Foege, EIS 1971 Larry Schonberger, EIS 1971 David Sencer, EIS 1975 Phil Brachman, EIS 1954 In Sudan Don Francis, EIS 1971

4 Ebola, Zaire, 1976 Spectrum of Emotion and Activity Emotion Activity Anxiety Terror Fear Confidence (false) Sorrow Uncertainty Understanding Anger Comfort (false) People fleeing Commission formed Chaos Isolation and quarantine Rapid Surveillance Investigations/ quick Patient management Field Investigations Active case detection Information Sharing Highest Less high High Low Celebration Plasmapheresis

5 Ebola Hemorrhagic Fever, DR Congo (Zaire), 1976: Team Members, Antwerp, 1996

6 Number of Cases of Ebola Hemorrhagic Fever in the Equator Region, by Day of Onset and Probable Type of Transmission, 1976 Probable Type of Transmission Cases SeptemberOctober 1-3 4-6 7-9 10-12 13-15 16-18 19-21 22-24 25-27 28-30 Person to Person Both Syringe 50 45 40 35 30 25 20 15 10 5

7 Ebola Virus, Zaire, 1976 Unfixed diagnostic specimen from Vero cell passage: sodium phosphotungstate x 90,000 (Fred Murphy)

8 Laboratory in Yambuku, DR Congo (Zaire), 1976 Guido van der Groen

9 Epidemiologists in Yambuku, DR Congo (Zaire), 1976 Peace Corps Volunteer, Joel Breman, Peter Piot, Pierre Sureau

10 Convalescent EHF Patient Undergoing Plasmapheresis, Yambuku, DR Congo (Zaire), 1976 Karl Johnson

11 Ebola Hemorrhagic Fever Team in Yambuku, DR Congo (Zaire), 1976

12 Evacuation of EHF Commission Member from Yambuku, DR Congo (Zaire), to Johannesburg, November 1976

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16 Ebola Virus Marburg Virus Both

17 Marburg and Ebola Virus Outbreaks from 1967-2000 The Filoviral Triangle Ebola Virus Marburg virus Both

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19 Locations of Outbreaks of Ebola Hemorrhagic Fever, Sudan and DR Congo (Zaire), 1976, and DR Congo (Zaire), 1995

20 Time of Onset of Ebola Hemorrhagic Fever by Transmission Type (after initial contact with source) DR Congo (Zaire), 1976

21 Flying along the Zaire River to Yambuku, DR Congo (Zaire), October 1976

22 Villages on the Bumba to Yambuku Road, DR Congo (Zaire), October 1976

23 Patient with Ebola Hemorrhagic Fever, Bumba Zone, Equateur Province, DR Congo (Zaire), October 1976

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