1. Isotope R&D Facility A proposed addition to the HRIBF driver upgrade Mike Saltmarsh HRIBF Users’ Meeting Nov 13 th 2009

2. 2Managed by UT-Battelle for the U.S. Department of Energy Presentation_name Proposed Isotope Production R&D Facility National Context There is a national need for a reinvigorated DOE isotope program – selected recommendations from NSAC report – “Support a sustained research program…. In the production and supply of isotopes….” – “Investment in new production capabilities” – “Investment in workforce development”

3. 3Managed by UT-Battelle for the U.S. Department of Energy Presentation_name Shared use of the C70 is unusually attractive A substantial allocation of beam time to the isotope program would be available ( ~ 4500h/yr) Little or no impact on the HRIBF mission or flexibility would be incurred Concurrent construction of the isotope facility would not significantly impact the C70 upgrade construction ORNL already has all the required isotope infrastructure from production through transportation The incremental capital cost to the isotope program would be modest (7-10M$) The opportunity to share operations costs would benefit both programs

4. 4Managed by UT-Battelle for the U.S. Department of Energy Presentation_name Elements of the proposed facility Dedicated isotope target vault Two beamlines from the C70 to the isotope vault Two target stations, one a commercially available standard, the other compatible with the BNL/LANL target systems Systems for remote transfer of the target modules from target station to transfer cell. A transfer cell to package irradiated modules for transfer to the ORNL hot cells Currently estimated total incremental cost is 7-10 M$ Items in red are part of the isotope facility

5. 5Managed by UT-Battelle for the U.S. Department of Energy Presentation_name IBA Solid Target System Specifications Maximum power dissipation of target assembly (on blank copper target): 12 kW Beam profile on target: Gaussian 6 mm FWHM, rotated to uniform flat beam Angle of target face to beam: 6 degrees

6. 6Managed by UT-Battelle for the U.S. Department of Energy Presentation_name Beams available from the C70 IonExtraction E min MeV E max MeV I max  A H-H- stripping3070750 D-D- stripping153550 H2+H2+ ESD-3550 α ESD-7050

7. 7Managed by UT-Battelle for the U.S. Department of Energy Presentation_name Important Characteristics of the C70 and it’s anticipated operating regimes Very high reliability (~ 95% for commercial C30) – Expectations for the HRIBF operating environment ~ 6600h/yr of extracted beam availability. 42 weeks, 156 h/week, 7 day operation. Dual extraction capability for negative ion beams – HRIBF needs for RIB production ~ 4000 h/yr – Most RIB production (3000h/yr) requires the full energy proton beam at intensities 50  A and higher – Allows simultaneous use of 70 MeV protons by isotope program. Independent intensity control (within limits) HRIBF operation includes periods of days-weeks when C70 beams not required – 1500-2000 h/yr of dedicated beams (including alphas) available for the isotope program

8. 8Managed by UT-Battelle for the U.S. Department of Energy Presentation_name Elements of the Proposed Isotope Program would address many of the needs identified in the NSAC report Radioisotope production R&D – New production regimes, eg for 225 Ac – Excitation functions, thick target yields – Nuclear and radiochemistry – High power target design Radioisotope Production – Research isotopes, eg 211 At, 68 Ge, 7 Be – Commercial Isotopes, eg 82 Sr, 68 Ge Education and Training

9. 9Managed by UT-Battelle for the U.S. Department of Energy Presentation_name Production R&D example Short-lived (46 m) alpha emitter 213 Bi offer great promise for radioimmunotherapy – Attach radionuclide to suitable antibody – Antibody preferentially attaches to tumor cell – Radiation delivered within ~100  of tumor cell, not elsewhere Supplies are limited, hindering clinical trials – Currently source is 233 U - 229 Th (7880y) - 225 Ac (10d) as a generator for 213 Bi – R&D required to investigate other possible production methods – Funded proposal to look at excitation functions and thick target yields for protons on 230 Th and 232 Th targets* at HRIBF – * garlandma@ornl.gov, stracenerdw@ornl.govgarlandma@ornl.govstracenerdw@ornl.gov

10. 10Managed by UT-Battelle for the U.S. Department of Energy Presentation_name ORNL Infrastructure Available for Education and Training Production R&D – Seek University partnerships Training programs using ORNL facilities – Production facilities – Hot cells for target processing – Radiochemistry labs – Animal facilities – Transportation Workshops – Workshop on next generation of radiochemists planned for spring 2010

11. 11Managed by UT-Battelle for the U.S. Department of Energy Presentation_name Shared use of the C70 is unusually attractive A substantial allocation of beam time to the isotope program would be available ( ~ 4500h/yr) Little or no impact on the HRIBF mission or flexibility would be incurred Concurrent construction of the isotope facility would not significantly impact the C70 upgrade construction ORNL already has all the required isotope infrastructure from production through transportation The incremental capital cost to the isotope program would be modest (7-10M$) The opportunity to share operations costs would benefit both programs