1. Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL1 Congenital anomalies 1993–2010 Statistical Report 1/2013 in figures Annukka Ritvanen Seija Sirkiä 15.10.2015

2. Congenital anomalies 1993-2010 In 1993–2010, the prevalence of births with major congenital anomalies remained rather stable. Annually major anomalies were detected on average in 3,5 per cent of births or in slightly more than 2000 births. The major periodic variations in the prevalence are associated with the reforms in the Malformation Register activities. The smaller random variation is due to the rarity of congenital anomalies. There were no significant differences between the data of the various malformation types for 2010 and data for previous years. During the follow-up period 1993–2010 an average of about 250 pregnancies were terminated annually because of major foetal structural anomalies and chromosomal defects. The number of selective terminations of pregnancy has slowly increased, being about 340 in 2010. 15.10.2015 2Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL

3. 15.10.2015 Miia Artama, projektipäällikkö, Stakes3 Figure 1. Prevalence of cases with major congenital anomalies (1/10 000 births) in 1993–2010. 3 15.10.2015 Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL

4. 15.10.2015 Miia Artama, projektipäällikkö, Stakes4 Figure 2. Proportion (%) of selective terminations of pregnancy of all cases with major anomalies in 1993–2010. [Selective terminations of pregnancy / (births + selective terminations of pregnancy)]. 4 15.10.2015 Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL

5. 15.10.2015 Miia Artama, projektipäällikkö, Stakes5 Figure 3. Prevalence of selective terminations of pregnancy (1/10 000 births) in 1993–2010. 5 15.10.2015 Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL

6. 15.10.2015 Miia Artama, projektipäällikkö, Stakes6 Figure 4. Prevalence of cases with major congenital anomalies (1/10 000 births) in the areas of special responsibility of the university hospitals in 1993–2010. 6 15.10.2015 Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL The areas of special responsibility of the university central hospitals HUCH =Helsinki and TUCH =Turku and university hospitals TAUH =Tampere, KUH =Kuopio and OUH =Oulu.

7. 15.10.2015 Miia Artama, projektipäällikkö, Stakes7 Figure 5. Proportion (%) of selective terminations of pregnancy performed for foetal abnormalities of all cases with major congenital anomalies in the areas of special responsibility of the university hospitals in 1993–2010. [Selective terminations of pregnancy / (births + selective terminations of pregnancy)]. 7 15.10.2015 Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL The areas of responsibility of the university central hospitals HUCH =Helsinki and TUCH =Turku and university hospitals TAUH =Tampere, KUH =Kuopio and OUH =Oulu.

8. 15.10.2015 Miia Artama, projektipäällikkö, Stakes8 Figure 6. Prevalence for anencephaly and spina bifida (1/10 000 births) in 1969–2010. 8 15.10.2015 AnencephalySpina bifida Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL

9. 15.10.2015 Miia Artama, projektipäällikkö, Stakes9 Figure 7. Proportion (%) of selective terminations of pregnancy of all pregnancies with anencephaly and spina bifida in 1981–2010. [Selective terminations of pregnancy / (births + selective terminations of pregnancy)]. 9 15.10.2015 Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL

10. 15.10.2015 Miia Artama, projektipäällikkö, Stakes10 Figure 8. Prevalence for Down syndrome (trisomy 21)(1/10 000 births) in 1993–2010. 10 15.10.2015 Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL

11. 15.10.2015 Figure 9. Prevalence for Down syndrome (trisomy 21) by maternal age groups (1/10 000 births) in 1993–2010. 15.10.2015 11Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL

12. 15.10.2015 Miia Artama, projektipäällikkö, Stakes12 Figure 10. Prevalence for Down syndrome (trisomy 21) (1/10 000 births) in 1991–2010; standardised and non- standardised by maternal age groups. 12 15.10.2015 1. Births and selective terminations of pregnancy 2. Births 3. Selective terminations of pregnancy 1. 3. Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL

13. 15.10.2015 Miia Artama, projektipäällikkö, Stakes13 Figure 11. Proportion (%) of selective terminations of pregnancy of all pregnancies with Down syndrome (trisomy 21) in 1993–2010. [Selective terminations of pregnancy / (births + selective terminations of pregnancy)]. 13 15.10.2015 Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL

14. 15.10.2015 Miia Artama, projektipäällikkö, Stakes14 Figure 12. Proportion (%) of selective terminations of pregnancy of all pregnancies with Down syndrome (trisomy 21) in 1993–2010 by maternal age groups. [Selective terminations of pregnancy / (births + selective terminations of pregnancy)]. 14 15.10.2015 Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL

15. 15.10.2015 Miia Artama, projektipäällikkö, Stakes15 Figure 13. Prevalence for orofacial clefts in births and in births and selective terminations of pregnancy (1/10 000 births) in 1974–2010. 15 15.10.2015 Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL

16. 15.10.2015 Miia Artama, projektipäällikkö, Stakes16 Figure 14. Total prevalence (1/10 000 births) for cleft palate (CP) and cleft lip with or without cleft palate (CLP) in 1974–2010. 16 15.10.2015 Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL

17. Links 15.10.2015 17 Congenital anomalies 1993−2010 Statistical Report 1/2013: –www.thl.fi/fi/statistics/congenitalmalformationswww.thl.fi/fi/statistics/congenitalmalformations www.thl.fi www.icbdsr.org www.eurocat-network.eu Statistical Report 1/2013 / Annukka Ritvanen and Seija Sirkiä / Malformation Register / THL