1. A Novel Dermoscopic Probe for Determining Elasticity Measurements of the Skin Group 7: Erica Bozeman Markesha Cook Stephanie Cruz November 14, 2006

2. Design Objective "Structural alterations within cancerous skin-lesions cause unexpected patterns of anatomical deformation in response to mechanical forces." Dr. Michael Miga create a novel dermoscopic imaging probe conduct phantom experiments design skin-friendly stretching apparatus

3. Skin Cancer Types of skin cancer Basal Cell carcinoma Squamous cell carcinoma Melanoma Risk Factors Chronic overexposure to sun Skin type Number of moles History Weakened immune system Areas Frequently Affected Face, neck, hand, shoulders, back, arms http://images.main.uab.edu/healthsys/ep_0137.jpg

4. Current Methods of Detection Physician Visual Inspection Biopsy Invasive Scarring Time Misdiagnosis Dermoscopy http://www.jfponline.com/images/5206/5206JFP_AppliedEvidence-fig4.jpg

5. Our Proposed Device Easy Non-invasive Quick Effective Cost-efficient

6. Design Specifications: Probe Design Metal/plastic shaft Apply controlled tensile stretch A few mm Adhesive applied to skin Crank ~ Crescent wrench Hold camera

7. Force Sensor Potential Design: Sony XCD- X710CR camera Mild Skin adhesive

8. Testing Methods Uniaxial Tension Simple Finite Element Method Viscoelastic parameters of the skin Independent Testing with the Bose ElectroForce © Elastography http://www.bose- electroforce.com/product.cfm?pid=41&sid=1

9. Budget Force Sensor $128.00-$195.00 Probe Materials $100.00 3M Micropore Surgical tape $10.00

10. Design Specifications: Thin Film Load Cell Strain Gauge Technology Mechanical motion  electronic signal Measures force/displacement Placed near stretching valve Cost:$195

11. Future Work Select force sensor Measure ~2-5 Newtons Research linear force actuators- valve Provide electric constant force Shaft material Acrylic vs. Metal http://www.beikimco.com/products/linearvoicecoil.php

12. Timeline

13. Important Design Dates End of January Fully functional probe Mid February Incorporate force sensors into probe design Mid March Comparative analysis using Dr. Miga’s model April Finalize results; prepare for design presentation

14. References www.skincancer.org http://www.eurekalert.org/pub_releases/2006-10/osoa-ltt101606.php http://www.smdsensors.com/detail_pgs/s100.htm http://www.omega.com/literature/transactions/volume3/strain.html M. I. Miga, M. P. Rothney, J. J. Ou, "Modality independent elastography (MIE): Potential applications in dermoscopy", Medical Physics, vol. 32, no. 5, pp. 1308-1320, 2005. Tsap, Leonid V. et al. Efficient Nonlinear Finite Element Modeling of Nonrigid Objects via Optimization of Mesh Models. Computer Vision and Image Understanding. Vol 69, No. 3 March 1998 pp. 330- 350. Wan Abas, W.A.B and J.C. Barbenal. Uniaxial Tension Test of Human Skin In Vivo. J. Biomed. Engng. Vol 4 January 1982 pp.65- 71.

15. Questions