1. Heart Stabilization Device Amir Durrani Ben Hoagland Santosh Tumkur Lucas Burton Advisor: Thomas P. Ryan, Ph.D.

2. Overview of CABG Coronary Artery Bypass Graft Procedure to introduce increased blood flow to occluded coronary arteries Harvested vessels grafted to coronary arteries Two methods: On-Pump and Off-Pump

3. On-Pump vs. Off-Pump On-Pump procedure is performed on an arrested heart and involves the use of a heart-lung machine Off-Pump procedure is performed on a beating heart and does not involve the use of a heart-lung machine

4. Problems Stabilization is required to perform CABG on a beating heart Current stabilizers don’t provide adequate local stabilization of graft site Heart positioning problems Heart hemodynamics

5. Objectives Develop a next generation heart stabilization device Introduce positioning options that minimize obstruction and optimize hemodynamics

6. Possible Solutions External mechanical stabilization (in use) Internal mechanical stabilization Chemical methods (ACH, Ca2+blockers) Electrical inhibition Virtual/mechanical stabilization Improving suturing techniques

7. Progress Made Met with multiple cardio-thoracic surgeons Observed both on and off-pump procedures Obtained information on competitors’ devices Acquired current Ethicon© stabilization device

8. Current Status Meeting with mechanical and biomedical engineers to discuss biomaterials and other design issues Acquiring access to animal hearts for prototype testing Ordered heart model Narrowing solution options

9. Future Plans Begin developing prototypes Continue researching possible solutions Continue consultation with surgeons and engineers for feedback Begin testing prototypes Alter design based on feedback and prototype test results