1. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Chapter 2 An Integrative Approach to Psychopathology

2. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology One-Dimensional vs. Multidimensional Models  One-Dimensional Models  Explaining behavior in terms of a single cause  Could mean a paradigm, school, or conceptual approach  Problem – Other information is often ignored  Multidimensional Models  Interdisciplinary, eclectic, and integrative  “System” of influences that cause and maintain suffering  Uses information from several sources  Abnormal behavior as multiply determined

3. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Multidimensional Models of Abnormal Behavior  Biological Factors (genetics, physiology, neurobiology)  Behavioral Factors  Emotional Influences  Social Factors  Developmental Factors

4. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Genetic Contributions to Psychopathology  Gregor Mendel's Work in the 19th Century  Phenotype vs. genotype  Nature of Genes  Deoxyribonucleic acid (DNA) – The double helix  23 pairs of chromosomes  Dominant vs. recessive genes  Development and behavior is often polygenetic  Genetic Contribution to Psychopathology  Less than 50%

5. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology The Interaction of Genetic and Environmental Effects  Eric Kandel and Gene-Environment Interactions  The Diathesis-Stress Model  Examples include blood-injury-injection phobia and alcoholism  Reciprocal Gene-Environment Model  Examples include depression, divorce, and impulsivity  Non-Genomic Inheritance of Behavior  Environmental influences may override genetic influences  Genes are not the whole story

6. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Neuroscience Contributions to Psychopathology  The Field of Neuroscience  The role of the nervous system in disease and behavior  Branches of the Human Nervous System  The central nervous system (CNS)  Brain and spinal cord  The peripheral nervous system (PNS)  Somatic and autonomic branches

7. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Neuroscience and the Central Nervous System  The Neuron  Soma – Cell body  Dendrites – Branches that receive messages from other neurons  Axon – Trunk of neuron that sends messages to other neurons  Axon terminals – Buds at end of axon from which chemical messages are sent  Synapses – Small gaps that separate neurons  Neurons Function Electrically, but Communicate Chemically  Neurotransmitters are the chemical messengers

8. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Overview: Neuroscience and Brain Structure  Two Main Parts  Brainstem and forebrain  Three Main Divisions  Hindbrain  Midbrain  Forebrain

9. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Neuroscience and the Divisions of the Brain  Hindbrain  Medulla – Heart rate, blood pressure, respiration  Pons – Regulates sleep stages  Cerebellum – Involved in physical coordination  Midbrain  Coordinates movement with sensory input  Contains parts of the reticular activating system (RAS)  Forebrain (Cerebral Cortex)  Most sensory, emotional, and cognitive processing  Two specialized hemispheres

10. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Major Structures of the Brain Figure 2.7b Major Structures of the Brain.

11. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Neuroscience and the Brain Structure  Lobes of Cerebral Cortex  Frontal – Thinking and reasoning abilities, memory  Parietal – Touch recognition  Occipital – Integrates visual input  Temporal – Recognition of sights and sounds and long-term memory storage  Limbic System  Thalamus – Receives and integrates sensory information  Hypothalamus – Eating, drinking, aggression, sexual activity

12. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Neuroscience: Peripheral Nervous and Endocrine Systems  Somatic Branch of PNS  Controls voluntary muscles and movement  Autonomic Branch of the PNS  Sympathetic and parasympathetic branches of the ANS  Regulates cardiovascular system & body temperature  Regulates the endocrine system and aids in digestion  The Endocrine System  Hormones  The Hypothalamic-Pituitary-Adrenalcortical Axis (HYPAC axis)  Integration of endocrine and nervous system function

13. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Neuroscience: Functions of Main Types of Neurotransmitters  Functions of Neurotransmitters  Agonists, antagonists, and inverse agonists  Most drugs are either agnostic or antagonistic  Main Types and Functions of Neurotransmitters  Serotonin (5HT)  Gamma aminobutyric acid (GABA) and benzodiazepines  Norepinephrine and beta blockers  Dopamine and L-Dopa

14. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Neuroscience: Functions of Main Types of Neurotransmitters (cont.) Figure 2.11 Major serotonin pathways in brain.

15. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Neuroscience: Functions of Main Types of Neurotransmitters (cont.) Figure 2.12 Manipulating serotonin in the brain.

16. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Implications of Neuroscience for Psychopathology  Relations Between Brain and Abnormal Behavior  Example: obsessive compulsive disorder  Example: schizophrenia  Psychosocial Influences  Can change brain structure and function  Therapy  Also changes brain structure and function  Medications and psychotherapy  Example: Depression  Psychosocial Factors  Interact with brain structures and function

17. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology The Contributions of Behavioral and Cognitive Science  Conditioning and Cognitive Processes  Respondent and operant learning  Learned helplessness  Modeling and observational learning  Social learning  Prepared learning  Cognitive Science and the Unconscious  Implicit learning  Blind sight  Stroop paradigm

18. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology The Role of Emotion in Psychopathology  The Nature of Emotion  To elicit or evoke action  Action tendency different from affect and mood  Intimately tied with several forms of psychopathology  Components of Emotion  Behavior, physiology, and cognition  Example of fear  Harmful Side of Emotional Dysregulation  Anger, hostility, emotional suppression, illness, and psychopathology

19. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Emotions influence on body

20. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Emotion Figure 2.16 Emotion has three important and overlapping components: behavior, cognition,and physiology.

21. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Cultural, Social, and Interpersonal Factors in Psychopathology  Cultural Factors  Influence form and expression of behavior  Gender Effects  Exerts a strong and puzzling effect on psychopathology  Social Effects on Health and Behavior  Frequency and quality are important  Related to mortality, disease, and psychopathology  Stigma of Psychopathology  Culturally, socially, and interpersonally situated

22. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Life-Span and Developmental Influences Over Psychopathology  Life-Span Developmental Perspective  Addresses developmental changes  Such changes influence and constrain  What is normal and abnormal  The Principle of Equifinality  Concept in developmental psychopathology  Several paths to a given outcome  Paths can vary by developmental stage  Example: Autism

23. Abnormal Psychology: An Integrative Approach, 4th Edition, David H. Barlow Chapter 2: An Integrative Approach to Psychopathology Summary of the Multidimensional Perspective of Psychopathology  Multiple Causation  Is the rule, not the exception  Helpful in explaining normal and abnormal behavior  Take a Broad, Comprehensive, Systemic Perspective  Biological  Psychological  Social, cultural, and developmental factors  Useful  To understand causes of psychopathology  How best to prevent and alleviate psychopathology