2. AHA Research Program Overview YOUR NAME HERE

3. Presentation Outline Mission and GoalsMission and Goals Budget PriorityBudget Priority Discoveries and AdvancementsDiscoveries and Advancements National, Affiliate and State Funding DataNational, Affiliate and State Funding Data Institutional SnapshotInstitutional Snapshot Affiliate ReorganizationAffiliate Reorganization National and Affiliate AwardsNational and Affiliate Awards Application Volume and Success RatesApplication Volume and Success Rates Application Process and TimelineApplication Process and Timeline Peer Review StructurePeer Review Structure Q&AQ&A

4. Mission & Impact Goal Mission "Building healthier lives, free of cardiovascular diseases and stroke" Impact Goal To reduce coronary heart disease, stroke and risk by 25% by 2010

5. Research AHA Top Priority The AHA believes that learning more about the #1 and #3 killers in America is one of the best ways to accomplish our mission. Knowledge Discovery is a strategic driving force in all that we do.

6. Research Goals Ensure that highly meritorious research and discovery continues, including supporting early career investigatorsEnsure that highly meritorious research and discovery continues, including supporting early career investigators Increase the capacity of the research community to generate the highest quality researchIncrease the capacity of the research community to generate the highest quality research Promote a research infrastructure that expedites the translation of basic, clinical, behavioral and population research into practicePromote a research infrastructure that expedites the translation of basic, clinical, behavioral and population research into practice

7. Publicly Donated Dollar Donor Dollar 28¢ 25¢ 75¢ National CenterSC Affiliate Research Allocation 15¢ 13¢

8. AHA’s 2005-06 EXPENDITURES AHA National Budget Expenditures

9. Research Expense for Major National Health Agencies: 2006 A American Cancer Society B Alzheimer’s Association C American Diabetes Association D National Multiple Sclerosis Society E March of Dimes F Muscular Dystrophy Association G Juvenile Diabetes Association H American Heart Association

10. AHA-Funded Breakthroughs AHA-funded research has led to the discovery and development of many treatments and procedures that were once more like science fiction: First artificial heart valveFirst artificial heart valve Techniques and standards for CPRTechniques and standards for CPR Implantable pacemakersImplantable pacemakers Treatment for infant respiratory distress syndromeTreatment for infant respiratory distress syndrome Cholesterol inhibitorsCholesterol inhibitors Drug-coated stentsDrug-coated stents MicrosurgeryMicrosurgery Links between dietary fat and cholesterolLinks between dietary fat and cholesterol

11. Selected Research Advancements All of the following were funded by the American Heart Association 1956 – Dr. Ancel Keys links dietary fat with cholesterol. 1957 – Dr. William Wierich joined by Drs. Vincent Gott and Walter Lillehei implant the first externally powered pacemaker. 1966 – Dr. Maurice Sokolow announces results of his 20-year study showing hypertension can decrease life expectancy. 1968 – Dr. William Connor employs holestyramine to lower cholesterol in the blood. 1972 – Dr. Arthur Guyton provides evidence of the overriding dominance of the kidneys in long-term regulation of blood pressure and in hypertension. 1985 – Dr. Joseph Goldstein and Dr. Michael Brown provide new insights into the ways fatty cholesterol enters body cells and why cholesterol levels my become too high. 1992 – Dr. Edwin Krebs joined by Dr. Edmond Fischer discover how proteins are switched to perform functions within the cells. 1998 – Dr. Andrew Marks develops a method to reduce re-blocking of the arteries after angioplasty. 2003 – Dr. Peter Agre discovers aquaporins, proteins that govern the movement of water in and out of cells.

12. National Research Statistics AHA has spent over $2.9 billion on research since 1949 and currently funds about 2,500 scientists around the countryAHA has spent over $2.9 billion on research since 1949 and currently funds about 2,500 scientists around the country AHA is second only to NHLBI in funding heart researchAHA is second only to NHLBI in funding heart research AHA spent almost $148 million on research last yearAHA spent almost $148 million on research last year AHA’s administrative costs represents only 3.9% ($5.7 of the $148 million spent)AHA’s administrative costs represents only 3.9% ($5.7 of the $148 million spent) AHA needed an additional $92.7 million to fund 608 highly meritorious applications that went unfunded last yearAHA needed an additional $92.7 million to fund 608 highly meritorious applications that went unfunded last year AHA has funded the winners of 9 Nobel PrizesAHA has funded the winners of 9 Nobel Prizes About 75% of the AHA’s award dollars support research career development – helping the scientists of tomorrowAbout 75% of the AHA’s award dollars support research career development – helping the scientists of tomorrow

13. SCA Research Statistics AHA is currently providing support to 197 researchers in 19 citiesAHA is currently providing support to 197 researchers in 19 cities AHA will spend $12 million supporting SCA research in 2008AHA will spend $12 million supporting SCA research in 2008 AHA currently has a research commitment of over $38 million in SCAAHA currently has a research commitment of over $38 million in SCA AHA received over 308 applications from SCA researchers in 2008AHA received over 308 applications from SCA researchers in 2008 AHA lacked the additional $8,304,474 to fund all the highly meritorious applications from SCA – even though our overall success rate was about 22%AHA lacked the additional $8,304,474 to fund all the highly meritorious applications from SCA – even though our overall success rate was about 22%

14. SCA State Overview Arkansas: 11 AHA awards worth $1,876,000 New Mexico: 12 AHA awards worth $1,848,856 Oklahoma: 10 AHA awards worth $1,452,924 Texas: 164 AHA awards worth $33,719,505

15. Reorganization Change in AffiliatesChange in Affiliates Effect on award offeringsEffect on award offerings Effect on peer reviewEffect on peer review

18. AHA Research Program The AHA supports research broadly related to cardiovascular function and disease, stroke or to related clinical, basic science, bioengineering or biotechnology, and public health problems. NATIONAL CENTER AWARDS: Clinical Research Program (NEW in 2008)Clinical Research Program (NEW in 2008) Scientist Development GrantScientist Development Grant Fellow-to-Faculty AwardFellow-to-Faculty Award Established Investigator AwardEstablished Investigator Award SOUTH CENTRAL AFFILIATE AWARDS: Predoctoral FellowshipPredoctoral Fellowship Postdoctoral FellowshipPostdoctoral Fellowship Beginning Grant-in-AidBeginning Grant-in-Aid Grant-in-AidGrant-in-Aid

19. National Awards Fellow-to-Faculty Transition Award To provide funding for trainees with outstanding potential for careers as physician-scientists in cardiovascular or stroke research during the crucial period of career development that spans the completion of research training through the early years of the first faculty/staff positionsTo provide funding for trainees with outstanding potential for careers as physician-scientists in cardiovascular or stroke research during the crucial period of career development that spans the completion of research training through the early years of the first faculty/staff positions Clinical Research Program (NEW) To encourage early career investigators who have appropriate and supportive mentoring relationships to engage in high quality introductory and pilot clinical studies that will guide future strategies for reducing cardiovascular disease and stroke while fostering new research in clinical and translational science, and encouraging community- and population-based activities.To encourage early career investigators who have appropriate and supportive mentoring relationships to engage in high quality introductory and pilot clinical studies that will guide future strategies for reducing cardiovascular disease and stroke while fostering new research in clinical and translational science, and encouraging community- and population-based activities.

20. Scientist Development Grant To support highly promising beginning scientists in their progress toward independence; bridges the gap between completion of research training and readiness for competition as an independent investigatorTo support highly promising beginning scientists in their progress toward independence; bridges the gap between completion of research training and readiness for competition as an independent investigator Established Investigator Award To support mid-term investigators with unusual promise, a rapidly growing research career and an established record of accomplishments; candidates have demonstrated commitment to cardiovascular or cerebrovascular science as indicated by prior publication history and scientific accomplishmentsTo support mid-term investigators with unusual promise, a rapidly growing research career and an established record of accomplishments; candidates have demonstrated commitment to cardiovascular or cerebrovascular science as indicated by prior publication history and scientific accomplishments offered only in July National Awards cont.

21. Programs Offered by the South Central Affiliate Predoctoral FellowshipPredoctoral Fellowship Postdoctoral FellowshipPostdoctoral Fellowship Beginning Grant-in-AidBeginning Grant-in-Aid Grant-in-AidGrant-in-Aid

22. Predoctoral Fellowship To inspire individuals to initiate careers in cardiovascular and stroke research and to support students conducting doctoral dissertation projects which broadly relate to the cardiovascular areas, including stroke. 1 or 2 years support at $23,000 per year.1 or 2 years support at $23,000 per year. Support limited to doctoral candidates enrolled in an accredited non-profit institution in Texas, Oklahoma, New Mexico or Arkansas.Support limited to doctoral candidates enrolled in an accredited non-profit institution in Texas, Oklahoma, New Mexico or Arkansas. Sponsor must be applicant’s major professor and may sponsor only one Affiliate Predoctoral Fellow at any one time. Any application for a new award that would exceed this limit will not be reviewed.Sponsor must be applicant’s major professor and may sponsor only one Affiliate Predoctoral Fellow at any one time. Any application for a new award that would exceed this limit will not be reviewed. Institutional supplementation permissible under certain conditions.Institutional supplementation permissible under certain conditions.

23. Postdoctoral Fellowship To provide stipend support to beginning investigators to further research training broadly related to the cardiovascular area, Including stroke. 1 or 2 years of support at $35,000 - $45,000 stipend, depending on years of training. Full-time research effort and sincere interest in pursuing a career in cardiovascular and/or stroke related research expected.Full-time research effort and sincere interest in pursuing a career in cardiovascular and/or stroke related research expected. Applicant must hold a doctoral degree and have less than 5 years of postdoctoral research training and experience at award activation (July 1, 2008).Applicant must hold a doctoral degree and have less than 5 years of postdoctoral research training and experience at award activation (July 1, 2008). Support limited to work within non-profit institutions in Texas, Oklahoma, New Mexico or Arkansas.Support limited to work within non-profit institutions in Texas, Oklahoma, New Mexico or Arkansas. Institutional supplementation permissible under certain conditions. Institutional supplementation permissible under certain conditions. An investigator may sponsor no more than two Affiliate Postdoctoral Fellows at any one time. Any application for a new award that would exceed this limit will not be reviewedAn investigator may sponsor no more than two Affiliate Postdoctoral Fellows at any one time. Any application for a new award that would exceed this limit will not be reviewed

24. Beginning Grant-In-Aid To promote the independent status of promising beginning scientists by supporting high quality, well-defined research projects in the cardiovascular area, including stroke. Two-years. Competitive renewal possible for up to 4 years of support, $70,000 per year maximum, including 10% overhead and up to 50% of total award for P.I. salary-related expenses. Applicants may have no more than $150,000 of extramural grant support per year, excluding P.I. and collaborating investigator salaries and indirect costs. Applicants must hold a doctoral degree. Limited to faculty (or equivalent staff) of non-profit institutions in Texas, Oklahoma, Arkansas and New Mexico, with a rank not exceeding Assistant Professor at award activation (July 1, 2008) Grants will not be awarded to supplement or duplicate any work that is being supported by other funding agencies. The only exceptions are career development awards.

25. Grant-In-Aid To support the most innovative and meritorious research projects from independent investigators in the cardiovascular area, including stroke. Two-years. (One-year requests permitted). Continuous support of any one investigator is limited to 4 years. $70,000 per year maximum, including 10% overhead and up to 50% of total award for P.I. salary-related expenses. Applicants may have no more than $250,000 of extramural grant support per year, excluding P.I. and collaborating investigator salaries and indirect costs. Applicants must hold a doctoral degree. Limited to faculty (or equivalent staff) of non-profit institutions in Texas, Oklahoma, Arkansas and New Mexico. Grants will not be awarded to supplement or duplicate any work that is being supported by other funding agencies. The only exceptions are career development awards.

26. 2008 Success Rate by Program ProgramApplicationsFundedSuccess% PRE28518% POST801823% BGIA872326% GIA1092220% TOTALS3046822%

27. Life Cycle of a Research Application Hmm … Application submitted An idea begins Peer Review Committee E-mail notification Research completed Yea! Reports Published Findings translated Assigned to reviewers Critique developed Rank- ordered list Research Committee $ Funded

28. Peer Review Structure Region III Review Consortium SCA Research Committee Consortium Steering Committee WSA Research Committee Peer Review Committees (10)

29. SCA Research Committee 11 members with a minimum of 2 from each of the four states11 members with a minimum of 2 from each of the four states Members serve 3 or 4 year termsMembers serve 3 or 4 year terms No more than 2 members serving from any one institutionNo more than 2 members serving from any one institution Diversity with regards to gender, PhD & MD, geography and expertiseDiversity with regards to gender, PhD & MD, geography and expertise Chair and Vice Chair each from different statesChair and Vice Chair each from different states Two meetings each year: Fall Conference call in November and Spring allocations meeting in MayTwo meetings each year: Fall Conference call in November and Spring allocations meeting in May Chair serves as leader (chair or co-chair) on consortium Steering CommitteeChair serves as leader (chair or co-chair) on consortium Steering Committee Responsibilities include: program menu, policy concerns, allocation of funds, promotion of programs and advisory role to affiliateResponsibilities include: program menu, policy concerns, allocation of funds, promotion of programs and advisory role to affiliate

30. Peer Review Study Groups 2007-08 Brain, Cardiorenal, Lung, Respiration, Surgery Behavioral Science, Epidemiology & Prevention, CV Regulation, Cardiac (Patho) Physiology, Radiology & Imaging CV Development, Immunology & Microbiology, Basic Cell & Molecular Biology Lipoproteins & Lipid Metabolism, Thrombosis, Vascular Wall Biology Cell Transport and Metabolism, Cellular CV Physiology & Pharmacology, Molecular Signaling

31. Science Areas Health Promotion/Prevention Human Nutrition (Behavioral and Preventive Aspects) Obesity Nutrition Outcomes Research Stroke Preventive Cardiology Quality of Life Social Support Systems Weight Control

32. Science Areas Basic Cell and Molecular BiologyBasic Cell and Molecular Biology Behavior StudiesBehavior Studies Biomedical EthicsBiomedical Ethics Cardiac RehabilitationCardiac Rehabilitation Clinical TrialsClinical Trials ComplianceCompliance Coping Strategies / Stress MgtCoping Strategies / Stress Mgt DepressionDepression EpidemiologyEpidemiology Exercise / Physical ActivityExercise / Physical Activity Familial Aggregation / Genetic EpidemiologyFamilial Aggregation / Genetic Epidemiology Health Care Utilization/Cost EffectivenessHealth Care Utilization/Cost Effectiveness

33. A New Application Process! What can you do in the meantime to prepare for the application process?What can you do in the meantime to prepare for the application process? –Notify your third parties that you plan to apply –Develop your research plan and specific aims –Begin to recruit referents if you are a fellow –Develop your training plan with your sponsor if you are a fellow –Check with your Grants Office for internal institutional deadlines –www.americanheart.org Please call our department at 650-259-6700 or email at research@heart.org with questionsPlease call our department at 650-259-6700 or email at research@heart.org with questionsresearch@heart.org

34. The Process South Central Affiliate JanuaryFebruaryMarch April May July Application Deadline Applications assigned to Committees Committee Chairs review assignments Committee Chairs finalize assignments Reviewers input preference Paper copies are sent to reviewers Peer Review Committee meets Research Committees meet Award Notification Award activation  September: online applications are available  November: institutional tour to promote program

35. Other AHA Scientific Products  AHA Professional Membership/Scientific Council  Scientific Statements/Guidelines  Scientific Sessions, Conferences and Workshops  AHA Scientific Journals  My.Americanheart.org

36. REMINDERS Research broadly related to cardiovascular function and disease, stroke, or to related basic science, clinical, bioengineering or biotechnology, and public health problemsResearch broadly related to cardiovascular function and disease, stroke, or to related basic science, clinical, bioengineering or biotechnology, and public health problems Consider criteria and evaluation prioritiesConsider criteria and evaluation priorities All basic disciplines as well as epidemiological, behavioral, community and clinical investigationsAll basic disciplines as well as epidemiological, behavioral, community and clinical investigations Citizenship: US, permanent resident, Visa, E-3, etc.Citizenship: US, permanent resident, Visa, E-3, etc. Sponsor criteria and support (see application instructions)Sponsor criteria and support (see application instructions) Budget amounts for stipend/salary, project support, fringe benefits, travel, indirect costs and maximum annual amountBudget amounts for stipend/salary, project support, fringe benefits, travel, indirect costs and maximum annual amount Eligibility by virtue of degree, faculty rank, independence, years of experience, percentage of effort, citizenship, sponsor support, restrictions, location of work and overlap of fundingEligibility by virtue of degree, faculty rank, independence, years of experience, percentage of effort, citizenship, sponsor support, restrictions, location of work and overlap of funding Repeat applications (up to 3 times including original)Repeat applications (up to 3 times including original)

37. QUESTIONS?.