1. Jehona Latifi Biochemistry 658

2. The Immune System  Innate Immunity Antigen-nonspecific defense system Examples: skin, stomach acid, mucus, etc.  Acquired Immunity Antigen-specific defense system Example: antibodies in the body

3. Inflammation  Response of the innate immunity to an invader inside the body.  The inflammation is due to blood and other defense cells that rush to the infected area.  Signs of inflammation include redness, swelling, heat and pain.

5. Prolonged Inflammation  When inflammation is prolonged, it causes problems inside the body.  It is said that inflammation and the innate immunity trigger many autoimmune diseases  Example: cancer  Cancer progresses due to growth factors and cytokines that are released by the inflammatory response.

9.  They are focusing on attacking the symptoms instead of the disease by treating inflammation and reducing cytokines  Reduction of inflammation and cytokines slows down the progression of the tumor  This would allow patients to live with a manageable disease instead of a non curable disease

10. References  Tan, Ting-Ting, and Lisa M Coussens. "Humoral Immunity, Inflammation And Cancer." Current Opinion In Immunology 19.2 (2007): 209-216. Academic Search Premier. Web. 12 Apr. 2012.  Varney, Michelle L., and Rakesh K. Singh. "The Role Of Inflammation In Tumor Progression: Targeting Tumor-Associated Macrophages." Clinical Research & Regulatory Affairs 25.3 (2008): 139-155. Academic Search Premier. Web. 12 Apr. 2012.  Wan-Wan, Lin, and Michael Karin. "A Cytokine-Mediated Link Between Innate Immunity,Inflammation, And Cancer." Journal Of Clinical Investigation 117.5 (2007): 1175-1183. Academic Search Premier. Web. 12 Apr. 2012.  Yale J Biol Med. 2006 December; 79(3-4): 123–130.Published online 2007 October.