1. http://sctr.musc.edu 843-792-8300 Smartphone Delivered Meditation for Blood Pressure Control Among Prehypertensives: A Pilot Feasibility Clinical Trial Subtitle Presenters Date Mathew Gregoski, Ph.D. Frank A. Treiber, Ph.D. (MUSC) Alexey Vertegel, Ph.D. Aleksey Shaporev, Ph.D. (Clemson) S.C. Smart State Technology Applications Center for Healthful Lifestyles (TACHL) MUSC Colleges of Nursing & Medicine Presented at: Verizon Wireless Health Technology Initiative Meeting, Nov. 15, 2011, Charleston, S.C.

2. Content http://sctr.musc.edu 843-792-8300 Rationale: Essential hypertension (EH) impacts 33% of US adults, higher prevalence among African Americans (AAs). EH is a significant risk factor for CVD, heart attack, stroke, renal failure. Leading predictor of EH is preEH (SBP/DBP 121-139/81-89 mmHg) Sustainable/easily disseminated prevention programs needed Breathing meditation shown to reduce BP among EH and preEH AA patients Smartphones enable large-scale/easy dissemination

3. http://sctr.musc.edu 843-792-8300 Proof of Concept Study Design and Methods Subjects: 3 adult prehypertensives (SBP > 120 mmHg) Procedures:  Received Tension Tamer, asked to practice 10 minute sessions 2x a day for 3-months  Measures collected at preintervention 1, 2, and 3 months: -Resting Hemodynamics and 24-Hour Ambulatory BP -Overnight Urine Sample -Awakening response saliva sampling

5. Approximately $450.00. Power drain from Bluetooth data transfer. Easy to lose.

6. Content TENSION TAMER http://sctr.musc.edu 843-792-8300 Presented by the COLLEGES of NURSING and MEDICINE

7. Welcome to Tension Tamer Introduction to Tension Tamer Teach Me to Meditate Go Directly to Meditation

8. http://sctr.musc.edu 843-792-8300 Proof of Concept Results Reductions in Salivary Alpha-Amylase awaking curve (Marker of SNS activity) from pre to post 3 month intervention. Dose-Response Reductions in 24 hour Ambulatory Blood Pressure. Reductions corresponded with Tension Tamer Adherence rates.

10. 24-Hour SBP as a function of adherence

11. http://sctr.musc.edu 843-792-8300 Future Pilot Feasibility Study Design and Methods Subjects: 30 stage 2 preEH adults (SBP 130-139 mmHg) Procedures:  Random assignment to Tension Tamer or standard of care 3 months  Measures collected at preintervention 1, 2, and 3 months: -Resting Hemodynamics and 24-Hour Ambulatory BP -Overnight Urine Sample -Repeated saliva sampling