1. Investigating motor-related sounds in the brain Zarinah Agnew, Carolyn McGettigan, Sophie Scott UCL Institute of Cognitive Neuroscience

2. 1. Is there somatotopy of action related sounds in motor cortices? 2. Is activity in speech sensitive areas influenced by linguistic status or by familiarity? – Somatotopy of action observation (mirror neurons) speech perception, observation of tactile stimulation, object-related sounds – Bodily produced actions in three modalities – mouth, hand and foot. – Widespread evidence that motor cortices are active during passive perception of speech but harder to prove role – Comparing passive listening of speech sounds (/f/ /ch/ /k/ /t/ ) and non speech sounds (clicks) produced by the mouth. These are familiar and can be recognised bilabial (kiss), alveolar (tsk), velar (clop and lateral (giddy-up). Hand sounds (claps, finger clicks). Feet sounds (footsteps on floor, stairs). Baseline – signal correlated noise versions.

3. Experimental design.. 6 conditions (speech, clicks, hand sounds, foot sounds, SCN and silence) Sparse design, pseudo jittered, 30 events, 6 conditions, 9sec TR: 27 minutes 3 sec stimuli 3 sec scan 2 sec ISI Want to capture this 1 to 2 seconds BOLD response @ 4 seconds after event: Scan at 5 to 6s 123456789 Last possible BOLD effect: 9 to 10s 1 sec Include localizer scan at end – cued to move mouth, hand or foot Include post-scan behavioural testing – any relationship between identification and activation. Include observation of same actions?

4. Experimental design.. Localiser runs (AT END OF SCAN) – Are the regions involved in perceiving action sounds, the same as those involved in producing those actions Block design (silent) – Hand movement (fist clench) – Mouth movement (open and shut mouth) – Foot crunch – Auditory localisers? – Rest 21sec block: repeated stimulation 3 sec instruction 4 repeats per condition: ~ 28 events for run 11 minutes

5. Experimental design.. Localiser runs (AT END OF SCAN) – Are the regions involved in perceiving action sounds, the same as those involved in producing those actions Block design (silent) – Observe hand movement (clap, finger click) – Observe mouth movement (speech sounds) – Observe mouth movement (non-speech sounds) – Observe foot movement (bare foot steps) – Observe moving dots or biological motion? – Rest 21sec block: repeated stimulation 3 sec instruction 4 repeats per condition: ~ 28 events for run 11 minutes