1. DynaPulse Non-invasive Blood pressure and Hemodynamic Monitoring Example Applications: Cardiac Rhythm & Hypertension Managements www.dynapulse.com Pulse Metric USA

2. Cardiac Rhythm Management: Pulse waveform of each measurement identifies cardiac rhythm…… Normal Every Time A Blood Pressure Measurement is Taken Arrhythmia

3. Pulse Waveform is Displayed for Each Measurement …… The adoption of DynaPulse technology by physicians will result in more patients with arrhythmias being identified and referred to the electro-physiologist and significantly improve the Cardiac Rhythm Management.

4. Managing 140/90 Borderline Hypertension with DynaPulse Case-1 had blood pressure of 140/91 with higher cardiac output (CO=8.42 vs. 4.25) and lower systemic vascular resistance (SVR=1016 vs. 2053), suggested case-1 use beta-blocker for treatment. Case-2: Had blood pressure of 142/91, but with lower brachial artery distensibility (BAD=4.49 vs. 6.46) and compliance (BAC=0.047 vs. 0.123), which indicated Case-2 had stiffer peripheral arterials and vessel-dilating drug ACEI was suggested.

5. Hypertension Management: Hemodynamic values provide beyond Systolic/Diastolic for managing hypertension…… Case 1 (140/91)Case 2 (142/91)

6. Hemodynamics in Hypertension Hemodynamic values provide beyond Systolic/Diastolic for managing hypertension……

7. Hypertension Management: Hemodynamic values provide beyond Systolic/Diastolic for managing hypertension…… Case 1 (140/91) ”Beta-Blocker…for high CO…” Case 2 (142/91) ”ACEI…for high SVR and low SVC, BAC & BAD…”

8. Advanced Clinical Applications: 24 Hour Ambulatory Blood Pressure & Hemodynamic Monitoring… 24-hr ABP can Identify Dippers, non-Dippers and over-dippers… It’s more predictive than office BP measurements

9. 24 Hour Ambulatory Blood Pressure Monitoring For type 1 Diabetics, an increase in systolic blood pressure during sleep precedes the development of microalbuminuria. NEJM 9/12/2002

10. The Advantage ABP 24-hr Brachial Artery Compliance Cardiac Output Systemic Vascular Resistance LV dP/dt DynaPulse  is the only technology that acquires blood pressures, central and peripheral hemodynamic values Simultaneously.

11. Whose Using It: Parke Davis

12. Whose Using It:

13. Thank you www. dynapulse.com