1. IGA Istituto di Genomica Applicata Institute of Applied Genomics Scientific & Technological Park, Udine, Italy at the roots of diversity

2. Legal information to understand the genetic variation underlying the phenotypic diversity to develop algorithms for the analysis of biological systems to promote the scientific culture and the advancement of the society to promote the technological innovation in agro-food Mission Research Institute (ONLUS) funded on April 13 th, 2006 legally recognised by FVG Regional Adiministration on August 4 th, 2008

3. The mission is targeted by multidisciplinary approaches bridging genetics, biochemistry, cell biology and bioinformatics that serve to: analyse structural and functional features of genomes study evolutionary dynamics of genomes and population genetics link genetic diversity with phenotypic variation discover the molecular basis of complex traits describe, simulate and predict biological processes through algorithms and bioinformatics tools characterise, protect and exploit natural resources relevant to agriculture, food and non-food industry promote innovation by transferring the results of research to the industry disseminate the scientific culture Research activity

4. Fields of Research strctural & functional genomics (genome sequencing and annotation...) bioinformatics (development of algorithms and tools for the management of genomic databases and the interpretation of functional DNA motifs) assisted breeding (development of breeding programs in food and non-food chains) molecolare diagnostic (genotyping platforms, forensic fingerprinting, comparative genomics and transcriptomics...)

5. Core facilities DNA sequencing core 4 ABI Prism 3730xl 96 capillary Sanger sequencers (5 Mb/giorno) 2 NG sequencers Illumina/Solexa GALII/ GALIIx (50 Gb/run) 1 NG sequencer Illumina/Solexa HiSeq2000 (200 Gb/run) 2 robots Beckmann, 9 PCRs... Centre of computational biology bar-coded pipeline and integrated LIMS for lab data management 64 bit cluster, 180 CPU-cores, 16 with parallel access at 128 GB RAM, 650 Gb RAM computational core 70 TB data storage proprietary software for data management, analysis and interpretation

6. Personnel Staff (17 people) Michele Morgante, molecular geneticist, CEO of IGA Federica Cattonaro, molecular biologist, CEO of IGA_TS Gabriele Di Gaspero, plant molecular geneticist Alessandro Gervaso, systems administrator Eleonora Di Centa, molecular biologist Erica Ietri, administration Irena Jurman, molecular biologist Moira Livon, molecular biologist Federica Magni, molecular biologist Fabio Marroni, molecular biologist Elena Misdariis, administration Felice Nicoletta, chemist Alberto Policriti, bioinformatician Simone Scalabrin, bioinformatician Alberto Stefan, molecular biologist Raffaele Testolin, plant geneticist Daniele Trebbi, plant geneticist Visiting scientists (3 people) Alberto Casagrande, University of Trieste, bioinformatician Rajora Om P, University of New Brunswick, forest geneticist Sugavanam Swaminathan, Univ. of Hyderabad, India, bioinformatician PhD students, Post-doc (7 people) Dario Copetti, molecular biologist Cristian Del Fabbro, bioinformatician Stefania Giacomello, molecular biologist Sara Pinosio, bioinformatician Alessandro Spadotto, molecular biologist Vera Vendramin, plant molecular geneticist Francesco Viezzi, engineer

7. Projects VIGNA/VIGNE. Grape genome sequencing project (MiPAF with Genoscope 2006-2010) Grape. Development of new grapevine varieties (FVG Region, 2007-2009) Grape. Genotyping grapevine varieties and clones (FVG winemakers, 2008-) Grape. Rapid analysis of secondary metabolite profiles (FVG Region, 2008-2010) Coffee. Quality-controlling genes (Illy Co, 2008) Barley. BAC end sequencing (IPK, Gatersleben, 2008-) Wheat. Marker-assisted breeding (Barilla SpA, 2008-) Wheat. Physical map of 4 chromosomes (EU Triticeae, 2008-) Wheat. Physical map of chromosome 5 (MiPAF, 2009-) Poplar. Energy poplar: gene mining (EU Energy Poplar, 2008-) Peach. Peach genome sequencing project (MiPAF-Drupomics with JGI-USA, 2009-) Citrus. Clementine genome sequencing (MiPAF Citromics with JGI-USA, 2009-) Bees. Studies on CCD (Colony Collapse Disease) (MiPAF, 2009-) … other projects on plants, animals, fishes, and microorganisms under negotiation …

8. Services DNA and RNA sequencing and re-sequencing genetic and physical maps individual genotyping production of genomic and cDNA libraries DNA sequence alignment and querries on gene banks analysis of DNA and set up of client-oriented software data storage, backup and remote access to data remote management of computing facilities clients Universities and public/private Research Institutes Hospitals Private Companies (seed firms, agro-industries...) Since September 2009 Services on demand are managed by IGA - TECHNOLOGY SERVICES

9. Contacts (1)Raffaele Testolin (2)Michele Morgante (3)Alberto Policriti (4)Gabriele Di Gaspero web site: www.appliedgenomics.org e-mail: info@appliedgenomics.org 1 2 3 4