1. Breast disease MUDr. Petr Šafář, CSc.

2. Anatomy of female breast

3. Breast examination

4. Benign breast disease Fibrocystic breast disease Adenosis – glandular prolif. Ductal hyperplasia – intraductal papilloma Cystosarcoma phyllodes – 80% benign fibroadenoma

5. Incidence of breast cancer

6. Breast cancer – age distribution

7. WHO classification Non-invasive carcinoma-ductal carcinoma in situ ( DCIS ) +lobular carcinoma in situ ( LCIS ) Invasive carcinoma - invasive ductal carcinoma (NST,NOS) invasive ductal carcinoma with dominant intraductal component, invasive lobular, carcinom mucinous, carcinom papillary, carcinom tubular, adenoid cystic carcinoma, carcinom sekretoric (juvenile) carcinoma apocrine, Paget´s carcinoma of breast nipple

8. Breast cancer treatment Surgery - radical mastectomy vs. Segmentectomy, TE+SLNB Adjuvant radiotherapy Adjuvantní chemotherapy Biologic therapy – herceptin Hormonal therapy

9. Complications of breast surgery Pneumothorax – radical mastectomy Vulneration of axillary vessels Vulneration of plexus brachialis Late complications – lymfoedema of prox.extr.