1. Delayed auditory feedback: a study into vocal motor patterns UCL Institute of Cognitive Neuroscience Dr Zarinah Agnew Dr Carolyn McGettigan Briony Banks Professor Sophie Scott

2. Background: Temporal asynchrony between speech production and its feedback to the auditory system causes: disruption of uent speech (Lee, 1950; Yates, 1963) slower speech rates, stuttering, intonation changes, and phoneme exchanges (Chapin et al., 1981). maximal disruptions at 200ms delay (Stuart et al., 2002).

3. Experimental Setup 4 sec stimuli 3 sec scan 2 sec ISI Want to capture this 1 to 2 seconds 30 events, 7 conditions, 10sec TR: 35 minutes 123456789 1 sec 1) Read aloud: minimal DAF feedback (50ms) 3) Read pseudo words: minimal DAF feedback (50ms) 2) Read aloud: maximal DAF feedback (200ms) 4) Read pseudo words : maximal DAF feedback (200ms) 8 conditions: 6) Passive listening 7) Rest 5) Mouthing read sentences See written sentences in all conditions apart from rest

4. Research Questions What neural structures are involved in adaptation to DAF? How does motor familiarity influence the DAF effect? - Compare early and late blocks - Compare normal and pseudo words/ sentences Activity in which regions predicts individual ability to speak under DAF? - Use behavioural performance scores (pre or post scan?) Suppression in auditory cortex? Efference copy for speech? - Reading aloud Vs listening and mouthing Cerebellum