1. Smallpox Divya Raj

3. History 3,000 years ago- Africa, Asia, Europe New World- 1400s-1500s

4. Variola (major/ minor) Orthopoxvirus, Poxiviridae Brick Linear double-stranded DNA

5. Smallpox Types Variola Vaccinia Cowpox Monkeypox

6. Transmission Airborne Bodily Fluids Contagious

7. Symptoms Fever Malaise Headache Fatigue Back Pain Vomiting, Diarrhea Rash- Spots, Blisters

8. Vs. Chickenpox Severity- Superficial Location- Trunk Type- Stage of lesions Timing- Contagiousness

9. 4 Types Ordinary- 90%, unvaccinated Modified- vaccinated Malignant- 5-10%, children Hemorrhagic- 2%, adults

10. Prognosis 30% overall 50-75% ordinary- confluent 25-30% ordinary- semi-confluent 90%- Flat 100%- Hemorrhagic 1%- Minor

11. Complications Scars- 65-85% Blindness- 2-5%

12. Treatment None Supportive Inoculation/ Variolation

13. Vaccine Edward Jenner 1796 Cowpox Side Effects

14. Eradication 1979 Atlanta, Koltsovo Destruction

15. Biological warfare Lack of vaccination

16. References http://www.pbs.org/wgbh/rxforsurvival/series/video/index. htmlhttp://www.pbs.org/wgbh/rxforsurvival/series/video/index. html http://www.pbs.org/wgbh/rxforsurvival/series/diseases/s mallpox.htmlhttp://www.pbs.org/wgbh/rxforsurvival/series/diseases/s mallpox.html http://www.who.int/mediacentre/factsheets/smallpox/en/ http://www.bt.cdc.gov/agent/smallpox/index.asp http://en.wikipedia.org/wiki/Smallpox http://www.nlm.nih.gov/exhibition/smallpox/sp_threat.htm lhttp://www.nlm.nih.gov/exhibition/smallpox/sp_threat.htm l http://www.mayoclinic.com/health/smallpox/DS00424/DS ECTION=symptomshttp://www.mayoclinic.com/health/smallpox/DS00424/DS ECTION=symptoms http://www.eduplace.com/science/hmsc/6/a/crick et/cktcontent_6a22.shtmlhttp://www.eduplace.com/science/hmsc/6/a/crick et/cktcontent_6a22.shtml