1. Funding Excellence in Research Mark Walport 2 December 2010

2. curiosity vs important questions

3. centuries-old diseases: malaria tuberculosis new and emerging threats: HIV avian influenza rise in chronic non-communicable disease: coronary heart disease diabetes obesity mental health reproductive, maternal & sexual health nutrition Important questions…

4. Wellcome Trust Five major challenges… maximising the health benefits of genetics and genomics investigating development, ageing & chronic disease understanding the brain combating infectious diseases connecting environment, nutrition and health

5. tax payer philanthropy industry Excellence in research Who should pay?

6. people career structure freedom of movement mentorship environments places infrastructure regulation Excellence in research How should it be supported?

7. Senior Investigator awards New Investigator awards People Wellcome Trust framework…

8. People - new in 2010: Wellcome Trust Investigators Key features… awarded on scientific vision & track record research question drives duration triage and interview for individuals that have university/institute tenure identifiable Wellcome community and alumni

9. university vs institute vs industry Environment

10. World class infrastructure

11. drivers to optimize academia & industry links develop innovative public private partnerships provide fiscal incentives: encouraging exploitation encouraging collaboration immigration: freedom of movement ensure regulation is facilitative and proportional: national and international regulation streamlined approval processes animals in research consent for consent health and safety Regulatory environment

12. new expectations fund a varied portfolio: best ideas best people infrastructure/resources translation fund in partnership: universities government industries charities/foundations The world post spending review

13. build on excellence catalysis and leverage institutional strategies greater collaboration: academic industry NHS translation health economic policy Making the whole greater than the sum of parts