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Pedigrees and Sex Linked Traits
Outcome I will explore how traits are inherited through generations by solving autosomal and sex-linked pedigrees.
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Sex Chromosomes X and Y are sex chromosomes
The other 22 pairs are autosomal(body) chromosomes Males = XY Females = XX Not true homologous pairs X has more genes
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X and Y Males Females Get Y from dad Get X from mom Get one X from dad
Get one X from mom
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Sex-linked traits X-linked
The inheritance pattern of genes located on the X chromosome
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Hemophilia Video
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X-Linked Punnett Square
Sex linked H=normal & h=hemophilia Cross: XHXh x XhY What is the chance that their son will have hemophilia? What is the chance that their daughter will have hemophilia? XH Xh XH Xh Xh Xh Y XH Y Xh Y 50% 50%
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Sex-linked worksheet Working with your table, complete the sex linked worksheet in your notes. You will have 6 minutes!
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Pedigrees a chart that shows how a trait (phenotype) is inherited through a family
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Pedigrees circles: females squares: males
shaded: individual with trait/disease Half-shaded: carriers for a trait but does not express the trait.
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Generation / Individual Practice
Generations are the rows in a pedigree Individuals are labeled across a pedigree Lines down represent offspring I II III
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What do we call this individual? Carrier
Quick Quiz Individual A is A male who expresses the trait A female who does not express the trait A male who does not express the trait A female who does express the trait What do we call this individual? Carrier
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Quick Quiz Individual D is A male who expresses the trait
A female who does not express the trait A male who does not express the trait A female who does express the trait
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Quick Quiz Individual H is A male who expresses the trait
A female who does not express the trait A male who does not express the trait A female who does express the trait
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Outcome I will explore how traits are inherited through generations by solving autosomal and sex-linked pedigrees.
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Fugates of Kentucky: Skin Bluer than Lake Louise
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Fugates of Kentucky: Skin Bluer than Lake Louise
Methemoglobinemia blood disorder with an abnormal amount of methemoglobin - a form of hemoglobin reduced ability to release oxygen to tissues - gives blood a bluish color
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Autosomal Recessive Trait appears only when two parents by chance carry the hidden allele Affected individual inherits both recessive alleles Example: sickle cell disease Who could be a carrier? Color in the carriers
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Autosomal Dominant Trait appears in every generation, in about half of descendants (assuming a heterozygous carrier) Affected individual has at least one dominant allele Example: Huntington’s disease
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X-linked Recessive Mother passes on to half of sons; half of daughters carry it. Father never passes on trait. Examples: Hemophilia, color blindness Why do more men have it? Who could be a carrier? Can men be carrier?
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X-linked Dominant Father passes trait to all daughters; no sons. Mother passes on to half of children. Example: Rett syndrome
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Outcome I will explore how traits are inherited through generations by solving autosomal and sex-linked pedigrees.
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