1. Assignment # Pedigrees
Biology
Mrs. McCarthy

2. Studying human heredity
Time between generations is
B. Number of offspring produced is
C. Controlled experiments are
too long.
too small.
not possible.

3. Pedigree charts –
A. This is the symbol for a female:
B. This is the symbol for a male:
A diagram that shows the
presence or absence of a trait in
each member of each generation

4. A normal person (no disease) -
A person with a disease:
A carrier of the disease:
has a clear symbol
has a solid or colored symbol
has a symbol that is half colored

5. Pedigree Symbols

6. Alkaptanuria
Alkaptanuria is a rare inborn error of metabolism of tyrosine due to deficiency of homogentisic acid (HGA) oxidase leading to accumulation of HGA in various tissues.The hallmark of the disorder is a triad of degenerative arthritis, ochronotic pigmentation and urine that turns black on alkalanization. Other manifestations of the disease include degenerative cardiovascular diseases. Treatment of the condition includes vitamin C that partially ameliorates the condition by impeding the polymerization of HGA.

8. METHEMOGLOBINEMIA is a disease caused by a blood disorder in which the blood does not appear red. Individuals may appear to have chocolate-brown lips or even blue skin.

9. Blue people of Kentucky

10. Blue Fugates of Kentucky

11. III. Example of a Pedigree
Look at your worksheet for the pedigree.
Are males or females more likely to have this disease?
How many females are carriers?
How many males are carriers?
Is this a sex-linked trait?

12. Draw a pedigree of a family that has:
Create a pedigree
Draw a pedigree of a family that has:
1. A mother that is a carrier for hemophilia
2. A father that is normal XH Y XH
XHXH
XHY
XHXh Xh
XhY

14. Create a pedigree
Draw a pedigree of a family that has:
1. A mother that is a carrier for hemophilia
2. A father that is normal
3. They have 2 daughters and 2 sons

15. 4. A carrier daughter marries a man with hemophilia
5. They have 2 daughters and 2 sons Xh Y XH
XHXh
XHY
XhXh
XhY

16. 4. A carrier daughter marries a man with hemophilia
5. They have 2 daughters and 2 sons

17. Example of a Pedigree

18. Make a pedigree to the song
“I’m my own grandpaw”

19. Can you make a Pedigree for this situation?
I’m my own grandpa!
Can you make a Pedigree for this situation?

20. `

21. Many, many years ago when I was twenty-three I was married to a widow who was pretty as could be. This widow had a grown-up daughter who had hair of red. My father fell in love with her and soon they, too, were wed.

22. This made my dad my son-in-law and changed my very life For my daughter was my mother, 'cause she was my father's wife. To complicate the matter, even though it brought me joy I soon became the father of a bouncing baby boy.

23. My little baby then became a brother-in-law to dad And so became my uncle, though it made me very sad For if he was my uncle, then that also made him brother To the widow's grown-up daughter, who, of course, was my step-mother.

24. Chorus I'm my own grandpaw I'm my own grandpaw It sounds funny I know but it really is so Oh, I'm my own grandpaw.

25. My father's wife then had a son who kept them on the run And he became my grand-child, 'cause he was my daughter's son. My wife is now my mother's mother, and it makes me blue Because, although she is my wife, she's my grandmother too.

26. If my wife is my grandmother, then I am her grandchild And every time I think of it, it nearly drives me wild (This has got to be the strangest thing I ever saw) As husband of my grandmother, I am my own grandpaw .

27. Chorus I'm my own grandpaw I'm my own grandpaw It sounds funny I know but it really is so Oh, I'm my own grandpaw.

28. HOMEWORK:
Pedigree worksheet