1. Surgical Planning Laboratory Brigham and Women’s Hospital Boston, Massachusetts USA a teaching affiliate of Harvard Medical School Overview Ron Kikinis, M.D.

2. ©2005 Surgical Planning Laboratory, ARR Slide 2 Overview Neurosurgery: –Alex Golby, Sandy Wells, CF Westin Prostate: –Clare Tempany, Noby Hata, Steve Haker Programmatic framework: –NAC Ron Kikinis, BIRN: Steve Pieper, IGT: Clare Tempany, Amigo: Randy Ellis

3. ©2005 Surgical Planning Laboratory, ARR Slide 3 Schedule Neurosurgery Prostate NCRR portfolio Discussion

4. ©2005 Surgical Planning Laboratory, ARR Slide 4 Neuroimage Analysis Center: NAC Biotechnology resource center Year 08 started on 8/1/2005 Algorithm development and software tools for basic and clinical neuroscience Cores: White Matter Architecture from DT-MRI, Clinical Computational Anatomy, Developmental Neuroinformatics, fMRI Informatics, Visualization Collaborations: Neurosurgery, Neurologic Imaging, Psychiatry

5. ©2005 Surgical Planning Laboratory, ARR Slide 5 Developmental Neuroanatomy fMRI Informatics WM Architecture from DT-MRI BIRN ProjectsClinical Computational Anatomy Visualization Technologies Technologies Registration Segmentation Visualization Modeling Variability Modeling Anatomy Modeling Biomechanics Filtering Systems Engineering Matrix Organization

6. ©2005 Surgical Planning Laboratory, ARR Slide 6 NAC: the Onion View

7. ©2005 Surgical Planning Laboratory, ARR Slide 7 NAC Focus: specific applications, custom software tools e.g. Tensor analysis for pioneering diffusion technology from BWH BIRN Focus: infrastructure, data, data distribution, computing e.g. Provides shared image databases and high speed network/computing for NA-MIC & NAC NA-MIC Focus: algorithms, engineering, general software tools e.g. Analysis of tensor and non-tensor diffusion data at three algorithm groups (UNC, Utah, MGH), hosted on BIRN servers from four clinical sites (Dartmouth, Harvard, UCI, U of Toronto) National Level Science National Level Outreach Advances in medical image computing Data repositories and access Data Requirements, testing, tools Interactions between NA-MIC, NAC, BIRN, IGT Local Level Science National Level Outreach IGT Focus: guided therapies, ilinical integration e.g. Guiding neurosurgery to minimize white matter damage

8. ©2005 Surgical Planning Laboratory, ARR Slide 8 NAC / BIRN / NA-MIC / IGT Interactions NAC –Neuroimaging Science that Leverages Unique Abilities of BWH and Close Collaborators –Widely Distributed and Disseminated BIRN –National Data, Networking, and Computation Infrastructure –Adapt and Apply Advanced Tools to Biomedical Problems through GCRC and other Clinical Partners NA-MIC –National Software Methodology and Novel Algorithms Drawing on Wide Range of Research Institutions –Establish Best Practices for Biomedical Application Software IGT –Leading Computation, Imaging, and Therapeutic Research in Closely Coupled Laboratory –Leverage NAC, BIRN, and NA-MIC for Clinical Application