1. This lesson will increase your knowledge of concepts covered in the following TEKS for biology: 4.b – Investigate and identify cellular processes including homeostasis, permeability, energy production, transportation of molecules, disposal of wastes, function of cellular parts, and synthesis of new molecules 5.c – Sequence the level of organization in multicellular organisms to relate the parts to each other and to the whole 9.a – Compare the structures and functions of different types of biomolecules 10.a – Interpret the functions of systems in organisms 10.b – Compare the interrelationships of organ systems to each other and to the body as a whole 11.a – Identify and describe the relationships between internal feedback mechanisms in the maintenance of homeostasis 11.b – Investigate and identify how organisms respond to external stimuli

2. Previous Lesson Diseases of the Endocrine System

3. Question: Would a person that is somewhat lethargic and overweight be suffering hyperthyroidism (high thyroid production) or hypothyroidism (low thyroid production)? Why?

4. Pituitary Thyroid Stimulating Hormone Thyroid Low Metabolism and High Weight Low Thyroxine Negative Feedback (inhibits hormone release) Hypothyroidism: Low Thyroxine Treatment: Synthetic thyroid pills

5. Question: If a person is in an area where a nuclear reactor has released radioactive iodine, why would authorities recommend they take iodine pills? From Harvard Health Letter

6. Destruction of nuclear reactor Release of radioactive iodine Uptake of radioactive iodine by thyroid Thyroid cancer Radioactive iodine causes mutations of DNA in thyroid cells Nuclear Reactor Accident Taking iodine in pills would block uptake of radioactive iodine by thyroid, thereby preventing cancer

7. Question: Why does a person with Type II diabetes have high blood sugar, and why is this so dangerous to a person’s health?

8. Type II Diabetes Cells of body become resistant to the effects of insulin Sugar cannot enter cells Concentrations of sugar in blood become too high Based on: Time, November 5, 1990

9. Effects of Uncontrolled Diabetes and High Blood Sugar Based on: Newsweek, September 4, 2000

10. Kidneys and the Urinary System Kidneys and the Urinary System Today’s Lesson

11. Major Parts of the Machine food, water intakeoxygen intake elimination of carbon dioxide Digestive SystemRespiratory System Circulatory System Urinary System elimination of excess water salts, wastes rapid transport to and from all living cells elimination of food residues nutrients, water, salts carbon dioxide water solutes oxygen Based on: Starr, C., Biology: Concepts and Applications, Brooks/Cole

12. Overview of Lesson Formation of urine Urinary system Water balance and alcohol Problems of the urinary tract

13. When protein is broken down in the body, it results in nitrogenous waste that must be eliminated from the body

14. Based on: Mader, S., Inquiry Into Life, McGraw-Hill Protein

15. All 20 amino acids have a nitrogen group (NH 2 ). When broken down for energy, the nitrogen group is converted to ammonia (NH 3 ). Examples of Amino Acids Based on: Mader, S., Inquiry Into Life, McGraw-Hill

16. Ammonia is converted into urea by the liver. Urea is then transported in the blood to the kidneys where the urea is removed from the blood. Circulatory System Based on: Mader, S., Inquiry Into Life

17. Urea is less toxic than ammonia and can be transported in the blood to the kidney H 2 N - C - NH 2 urea O

18. Formation of Urine Amino acids in protein are broken down, resulting in production of ammonia Ammonia is converted to urea in liver Urea travels in blood to kidneys, where removed from blood and incorporated into urine

19. Overview of Lesson Amino acids, ammonia and urea Urinary system Water balance and alcohol Problems of the urinary tract

20. Urinary System Based on: Mader, S., Inquiry Into Life, McGraw-Hill

21. Anatomy of the Kidney Based on: Mader, S., Inquiry Into Life, McGraw-Hill

22. Urine Formation by Nephron Blood pressure forces water, glucose, amino acids and urea from capillaries into nephron Glucose and amino acids are reabsorbed into blood from nephron Some water is reabsorbed into blood Urine is urea and salt concentrated in water

23. Nephron Based on: Mader, S., Inquiry Into Life, McGraw-Hill

24. Urine moves from the collecting ducts through the kidney pelvis to the ureter Based on: Mader, S., Inquiry Into Life, McGraw-Hill

25. Urine moves from the kidneys, through the ureters to the bladder and finally through the urethra Based on: Mader, S., Inquiry Into Life, McGraw-Hill

26. Overview of Lesson Amino acids, ammonia and urea Urinary system Water balance and alcohol Problems of the urinary tract

27. Regulation of Water Balance Brain monitors water content of blood If low water content, pituitary releases ADH ADH travels in blood to nephron ADH causes more water to move from urine back into blood

28. Nephron Based on: Mader, S., Inquiry Into Life, McGraw-Hill

29. Alcohol consumption suppresses the production of ADH by the pituitary. Why would this result in dehydration and a hangover?

30. Alcohol Effects Alcohol suppresses ADH production by the pituitary Without ADH, higher amounts of water stay in the urine Urine with high concentrations of water leaves the body

31. Overview of Lesson Amino acids, ammonia and urea Urinary system Water balance and alcohol Problems of the urinary tract

32. Incontinence (urine leakage) More than 10 million Americans experience incontinenceMore than 10 million Americans experience incontinence Most do not seek treatmentMost do not seek treatment Treatment can improve or eliminate the problem 90% of the timeTreatment can improve or eliminate the problem 90% of the time

33. Causes of Incontinence Stress incontinence: leaking small amounts of urine when coughing, lifting, or exercising Urge incontinence: the bladder suddenly and unexpectedly contracts and expels urine Overflow incontinence: bladder cannot completely empty so urine dribbles

34. Treatments for Incontinence Kegel exercises to strengthen the urinary sphincterKegel exercises to strengthen the urinary sphincter Medicines that increase the sphincter’s ability to contractMedicines that increase the sphincter’s ability to contract Surgery to strengthen the pelvic muscles or to lift the bladderSurgery to strengthen the pelvic muscles or to lift the bladder Retrain the bladder to increase its storage capacity (allowing 3-4 hours between urinating)Retrain the bladder to increase its storage capacity (allowing 3-4 hours between urinating) Drugs to prevent urge incontinenceDrugs to prevent urge incontinence Surgery to remove part of prostate gland if responsible for overflow incontinenceSurgery to remove part of prostate gland if responsible for overflow incontinence

35. Kidney stones form in the kidney pelvis. There are 4 types of stones. Calcium stones (most common) Uric acid stones Bacteria caused stones Cystein stones Based on Mayo Clinic Health Letter

36. Kidney stones cause pain when they pass down the ureters to the bladder and urethra Based on: Mader, S., Inquiry Into Life, McGraw-Hill

37. Treatments for Kidney Stones Small stones may pass with no painSmall stones may pass with no pain Larger stones may pass but cause extreme of pain, requiring a lot pain medicationLarger stones may pass but cause extreme of pain, requiring a lot pain medication Stones that are too large to pass may require surgical treatment including:Stones that are too large to pass may require surgical treatment including: – using a ureteroscope to go up and snare the stone – using a nephroscope to crush the stone and retrieve it –using shock wave lithotripsy where a person is submerged in water containing shock waves to pulverize the stones

38. Urinary Tract Infection (UTI) Second most common infection following respiratory infectionsSecond most common infection following respiratory infections UTI occur when bacteria (E. coli) from the digestive tract get into the opening of the urinary tract and multiplyUTI occur when bacteria (E. coli) from the digestive tract get into the opening of the urinary tract and multiply Bacteria first infect the urethra, then move to the bladder and finally to the kidneysBacteria first infect the urethra, then move to the bladder and finally to the kidneys UTI tend to occur more in women than menUTI tend to occur more in women than men

39. Women may have more UTIs than men because: 1)they have a shorter urethra, allowing quicker access to the bladder 2)the urethral opening is nearer the anus 3)intercourse may result in UTIs in women Based on: Harvard Medical School Family Health Guide

40. Symptoms of UTIs Urge to urinate but only small amount of urine producedUrge to urinate but only small amount of urine produced Pain and burning sensation in bladderPain and burning sensation in bladder FeverFever Blood in urineBlood in urine

41. Diagnosis and Treatment Doctors check urine for white and red blood cells and bacteriaDoctors check urine for white and red blood cells and bacteria Bacteria grown in culture to determine which antibiotic will work the bestBacteria grown in culture to determine which antibiotic will work the best UTIs are treated with antibiotics and are often cured within 1 or 2 daysUTIs are treated with antibiotics and are often cured within 1 or 2 days

42. Kidney Disease and Ethnicity Kidney disease 26 million AmericansKidney disease 26 million Americans African Americans five times likely to require dialysis or kidney transplantAfrican Americans five times likely to require dialysis or kidney transplant Possible reasonsPossible reasons –Lack of health care –Genetic component –Diabetes –Hypertension

43. Next Class Exam II (Lessons and Labs)