1. Objectives Discuss the history of breast cancer. Describe the pathology of breast cancer and list significant tumor markers. Differentiate IHC testing from FISH testing for HER2 markers. List the treatment options for metastatic breast cancer. Explain how monoclonal antibodies function. Learn how to administer Herceptin ® (trastuzumab) to patients. Understand the nurse’s role in HER2 testing and follow-up treatment of metastatic breast cancer. Discuss the history of breast cancer. Describe the pathology of breast cancer and list significant tumor markers. Differentiate IHC testing from FISH testing for HER2 markers. List the treatment options for metastatic breast cancer. Explain how monoclonal antibodies function. Learn how to administer Herceptin ® (trastuzumab) to patients. Understand the nurse’s role in HER2 testing and follow-up treatment of metastatic breast cancer.

2. Breast Cancer Origins Breast profile: A.Ducts B.Lobules C.Dilated section of duct to hold milk D.Nipple E.Fat F.Pectoralis major muscle G.Chest wall/rib cage Enlargement: A.Normal duct cells B.Basement membrane C.Lumen (center of duct) Breast profile: A.Ducts B.Lobules C.Dilated section of duct to hold milk D.Nipple E.Fat F.Pectoralis major muscle G.Chest wall/rib cage Enlargement: A.Normal duct cells B.Basement membrane C.Lumen (center of duct)

3. Non-Invasive versus Invasive Cancer Normal Cells Non-Invasive Cells Invasive Cells Normal Cells Non-Invasive Cells Invasive Cells

4. Types of Breast Cancer Ductal Carcinoma in situ (DCIS) Lobular Carcinoma in situ (LCIS) Invasive Ductal Carcinoma (IDC) Invasive Lobular Carcinoma (ILC)