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U n i v e r s i t y o f P e n n s y l v a n i a Learning about diffuse optics & its physiological applications with Britton Chance Arjun G. Yodh University.

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Presentation on theme: "U n i v e r s i t y o f P e n n s y l v a n i a Learning about diffuse optics & its physiological applications with Britton Chance Arjun G. Yodh University."— Presentation transcript:

1 U n i v e r s i t y o f P e n n s y l v a n i a Learning about diffuse optics & its physiological applications with Britton Chance Arjun G. Yodh University of Pennsylvania Department of Physics & Astronomy 30 co-authored papers ~1990-2010 (Britt, ~80-100 years-old; Arjun ~30-50) Personal (myopic) account

2 U n i v e r s i t y o f P e n n s y l v a n i a How do you look inside a glass of milk? Ice in WaterIce in Milk?

3 U n i v e r s i t y o f P e n n s y l v a n i a Why is this hard? WaterWater + Little MilkMilk Light doesn’t get Absorbed, it Scatters

4 U n i v e r s i t y o f P e n n s y l v a n i a The Dream (Sci-Fi Community) from: Minority Report from: Star Trek

5 U n i v e r s i t y o f P e n n s y l v a n i a The Dream: Britton Chance Near Infrared Light Penetrates Tissue Non-invasive, safe, rapid, portable, continuous, inexpensive,...

6 U n i v e r s i t y o f P e n n s y l v a n i a 1951: Supressing Scattering in Biological Media

7 U n i v e r s i t y o f P e n n s y l v a n i a Britt Really Wanted to Measure Hemodynamics/Metabolic Processes in Living Tissue Near Infrared Light Penetrates Tissue

8 U n i v e r s i t y o f P e n n s y l v a n i a “Birth” of Diffuse Biomedical Optics More than 1,000 citations.

9 U n i v e r s i t y o f P e n n s y l v a n i a 1988: Penn Physics Department "Random" Walk Brownian Motion in Concentrated Solutions. (Diffusing-wave Spectroscopy)

10 U n i v e r s i t y o f P e n n s y l v a n i a PhD Students! David Boas Maureen O’Leary

11 U n i v e r s i t y o f P e n n s y l v a n i a Diffusive Wave Optics Boas, Oleary, Chance, Yodh. Physical Review E, 47(5) 1993. Oleary, Boas, Chance, Yodh. Physical Review Letters, 69 1992.

12 U n i v e r s i t y o f P e n n s y l v a n i a Fluorescence Objects in Turbid Media!

13 U n i v e r s i t y o f P e n n s y l v a n i a “First” Tomographic Imaging Experiments with Diffusive Waves One Year Later, Fluorescence Concentration/Lifetime Tomography

14 U n i v e r s i t y o f P e n n s y l v a n i a RF Electronics Lock-In Amplifier (my solution, $2,000) IQ-chip (Britt's solution, $100) IT'S BETTER TO KNOW WHAT'S INSIDE THE BLACK BOX.

15 U n i v e r s i t y o f P e n n s y l v a n i a Other Diversions for Britt: Phase-Arrays 2010, still working on problem (persistence).

16 U n i v e r s i t y o f P e n n s y l v a n i a Living Things! Tissue Hemodynamics Spectral Fingerprints enable determination of tissue composition. Spectroscopy

17 U n i v e r s i t y o f P e n n s y l v a n i a BREAST CANCER

18 U n i v e r s i t y o f P e n n s y l v a n i a Combining Favorite Techniques: MRI + Optical (First Breast Cancer Studies)

19 U n i v e r s i t y o f P e n n s y l v a n i a Diffuse Optical Tomography of Breast

20 U n i v e r s i t y o f P e n n s y l v a n i a Differentiation Benign/Malignant

21 U n i v e r s i t y o f P e n n s y l v a n i a Invasive Ductal Carcinoma 53-year-old post-menopausal female, 2.2 cm invasive ductal carcinoma rTHC – HemoglobinrStO 2 – Oxygen Sat. r  ʹ s – Scattering rHbO 2 – OxyhemoglobinrHb – Deoxyhemoglobin

22 U n i v e r s i t y o f P e n n s y l v a n i a Fluorescence Diffuse Optical Tomography

23 U n i v e r s i t y o f P e n n s y l v a n i a Fluorescence Diffuse Optical Tomography (Large Contrast) 4-fold increase in ICG concentration. rTHCrStO 2 rs’rs’ rICG 1.09  0.030.91  0.021.82  0.933.74  0.77 Difference between hypervascularized and leaky regions.

24 U n i v e r s i t y o f P e n n s y l v a n i a Inspiration from BC: Functional Activation In Brain THC = Total Hemoglobin Concentration StO 2 = Blood Oxygen Saturation rBF = Relative Blood Flow CMRO 2 = Rate of Cerebral Oxygen Metabolism

25 U n i v e r s i t y o f P e n n s y l v a n i a Motor Stimulus: Optical Durduran, T., Yu, G., Burnett, M.G., Detre, J.A., Greenberg, J.H., Wang, J., Zhou, C., and Yodh, A.G., Diffuse optical measurement of blood flow, blood oxygenation and metabolism in human brain during sensorimotor cortex activation. Optics Letters 29, 1766-1768 (2004).

26 U n i v e r s i t y o f P e n n s y l v a n i a Realizing Britt’s Vision

27 U n i v e r s i t y o f P e n n s y l v a n i a Community Building Organize, Organize, Organize, Workshops and Conferences Promote, Promote, Promote young people, Penn Pool Intellectual Property so scientists get a piece of the pie Stay “focused” on the science (a marathon, not a sprint) Competitive, but Collegial and Collaborative Legacy: A Very Friendly & Productive Biomedical Optics Community. with Bruce Tromberg

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