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Andrew Smith Dietary patterns in the ALSPAC cohort: Cluster analysis EUCCONET International Workshop 18th October 2011
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Andrew Smith Dietary patterns in the ALSPAC cohort: Cluster analysis Pauline Emmett P. K. Newby Kate Northstone World Cancer Research Fund
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Dietary patterns Examine diet as a whole Start with many variables (e.g. FFQ, diet diary) Express as a small number of variables Image: Paul / FreeDigitalPhotos.net
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Principal components analysis (PCA) Examine diet as a whole Start with many variables (e.g. FFQ, diet diary) Use correlations between foods Express as a small number of components Image: Paul / FreeDigitalPhotos.net
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Cluster analysis Examine diet as a whole Start with many variables (e.g. FFQ, diet diary) Use similarities between people Express as a small number of clusters Image: Paul / FreeDigitalPhotos.net
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Dietary patterns studies in ALSPAC SourcePCACluster Mothers FFQNorthstone and Emmett, 2008a Partners FFQNorthstone and Emmett, 2010 FFQ age 3North, Emmett et al. 2000 FFQ age 4½Northstone, Emmett et al. 2005 FFQ age 7Northstone, Emmett et al. 2005Smith et al. 2011 FFQ age 9Northstone and Emmett, 2008b Diet diary age 10in submission FFQs age 13in submission
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Case study: PCA of FFQ age 7 Northstone and Emmett, 2005 Image: Suat Eman, winnond / FreeDigitalPhotos.net Junk Traditional Health conscious
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Dietary patterns studies in ALSPAC SourcePCACluster Mothers FFQNorthstone and Emmett, 2008a Partners FFQNorthstone and Emmett, 2010 FFQ age 3North, Emmett et al. 2000 FFQ age 4½Northstone, Emmett et al. 2005 FFQ age 7Northstone, Emmett et al. 2005Smith et al. 2011 FFQ age 9Northstone and Emmett, 2008b Diet diary age 10in submission FFQs age 13in submission
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Cluster analysis k-means is most widely-used method Must avoid pitfalls –Standardization –Algorithm –Reliability Image: Boaz Yiftach / FreeDigitalPhotos.net
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Dietary patterns studies in ALSPAC SourcePCACluster Mothers FFQNorthstone and Emmett, 2008a Partners FFQNorthstone and Emmett, 2010 FFQ age 3North, Emmett et al. 2000 FFQ age 4½Northstone, Emmett et al. 2005 FFQ age 7Northstone, Emmett et al. 2005Smith et al. 2011 FFQ age 9Northstone and Emmett, 2008b Diet diary age 10in submission FFQs age 13in submission
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Case study: cluster analysis of FFQ age 7 FFQ administered to ALSPAC children at 81 months of age Input variables are the same as PCA (Northstone, Emmett et al. 2005) 8,279 children 3 clusters Smith et al. 2011
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Case study: cluster analysis of FFQ age 7 Processed4177 children White bread Processed meat Fizzy drinks Ice cream Crisps Chips Squash Biscuits and sweets Plant- based 2065 children Brown/wholemeal bread Fruit and vegetables Vegetarian foods Pasta Rice Cereals Traditional British 2037 children Meat Potatoes Full-fat milk
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Similarities with PCA
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Cluster analysis of diet diary data 7473 children aged 10 Advantages –Similar 3-cluster solution (Processed, Plant-based, Traditional British) –Good separation between clusters Disadvantages –Not robust to under-reporting –PCA shows better associations with fat mass
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Dietary patterns studies in ALSPAC SourcePCACluster Mothers FFQNorthstone and Emmett, 2008a Partners FFQNorthstone and Emmett, 2010 FFQ age 3North, Emmett et al. 2000 FFQ age 4½Northstone, Emmett et al. 2005 FFQ age 7Northstone, Emmett et al. 2005Smith et al. 2011 FFQ age 9Northstone and Emmett, 2008b Diet diary age 10in submission FFQs age 13in submission
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Dietary patterns studies in ALSPAC SourcePCACluster Mothers FFQNorthstone and Emmett, 2008a. Br J Nutr. 99 p.1099-106 Partners FFQNorthstone and Emmett, 2010. EJCN 64 p.978-86 FFQ age 3North, Emmett and the ALSPAC Study Team, 2000. EJCN 54 p.73-80 FFQ age 7Northstone, Emmett and the ALSPAC Study team, 2005. EJCN 59 p.751-60 Smith, Emmett, Newby, Northstone 2011. EJCN 65 p.1102-9 FFQ age 9Northstone and Emmett, 2008b. Br J Nutr 100 p.1069-76 Diet diary age 10in submission FFQs age 13in submission
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