1. Prof. Massimo Massi Benedetti Chairman IDF European Region Department of Internal Medicine -University of Perugia (I) THE DIABETIC TIME BOMB IN EUROPE “Round Table” European Parliament Brussels Members Salon Tuesday 5th November 2002

2. THE INTERNATIONAL DIABETES FEDERATION The mission of the International Diabetes Federation is to work with our member associations to enhance the lives of people with diabetes

3. IDF Regions

4. Total population: 655 millions People with diabetes:22.5 millions Member associations:59 Countries represented:41 IDF European Region

5. The estimated prevalence and numbers of type 2 diabetes mellitus by IDF region, year 2000

6. Differences in the prevalence of type 2 diabetes among selected ethnic groups

7. Prevalence in different countries in the year. (%)  1994  2000

8. Diabetes prevalence in different age classes Prevalence (%) Age classes

9. Proportion of adolescent obesity Whites Blacks AmericanIndians % Obese Barry et al, J. Nutr. 1998 24.0 30.6 42.3

10. Estimates of magnitude of T2DM in North American children StudyYearAgeEstimates* (Years)(%) San Diego, CA19940-168 Cincinnati, OH19940-1916 San Antonio, TX19970-1618 Ventura, CA19940-17 45 Charleston, SC19970-1946 *Percentage of T2DM among new cases of diabetes

11. Impaired Glucose Tolerance IGT is characterised by raised blood glucose after meals (post-prandial hyperglycaemia), with near-normal fasting blood glucose IGT usually progresses to type 2 diabetes

13. Results from the Hoorn Study: 28 % of the subjects with IGT at baseline have developed type 2 diabetes within 2 years of study duration This is equivalent to a progression rate of 13.8% per year Rate of progression of impaired glucose tolerance to type 2 diabetes

14. Diabetes mellitus Regional estimates 1995 - 2025 Africa Americas Eastern Europe South-Est Western Mediterranean Asia Pacific Million of individuals