1. Student: Halip(Asofronie) Georgiana Coordinator: Sef lucrari Pop-Radu Corina Cristina Department of Endocrinology Targu Mures

2. AUTOIMMUNITY Disbalance of the immune system Global growing incidence Among the leading causes of death in young and middle-aged women

3. AUTOIMMUNE THYROID DISEASES Genetic, environmental and immunological factors T cell mediated autoimmune process TSH receptor, peroxidase, thyroglobulin  Most common organ-specific autoimmune diseases  Prevalence: 500 per 100.000 persons

4. Autoimmune hypothyroidism hyperthyroidism Classification Hashimoto thyroiditis Basedow- Graves disease

5. Diagnosis

6.  Disbalance in the immune system  Unable to recognize self tissues  Tissues tagged as non-self  Autoantibodies attack or direct distruction  Autoreactivity is present in all individuals but it doesn’t necessary imply pathogenic responses AUTOIMMUNE DISEASES

8. Autoimmune diseases tend to coexist in the same pacients Tendency mostly seen in organ specific autoimmune diseases Genetic evidences – some genes are responsible for more autoimmune diseases

9. Retrospective study 407 pacients with TAD Department of endocrinology

10. Sex distribution Mean ages

13. Coexisting autoimmune diseases

14. Autoimmune diseases found in women with ATD

15. Autoimmune diseases found in men with ATD

16.  The sex distribution shows a female prevalence for ATD  The mean age showed no significant difference women/men  Study – 16 associated AiD  The most prevalent coexisting AiD in subjects with ATD was Addison’s disease (HLA-DR3/DR4 correlation, AD pattern)  The other AiD following Addison’s disease in prevalence were DM type I and psoriasis (Studies regarding autoimmune correlations, demonstrated a high interrelationship between ATD and DM type I: 2,9-3,2 % in adults and 19-23,4% in children )  There were major differences in the associated AiD in men and women. The women were affected by more different AiD(all 16 AiD), meanwhile in men were reported only 3 other AiD associated(Addison d., psoriasis and DM I)  There weren’t AiD found exclusively in men Discussions

17.  Assessing the fact that in general population the prevalence of autoimmune diseases is smaller (5,3%) and includes the autoimmune thyroid diseases who are on a high prevalence, we can conclude that in pacients with a thyroid autoimmune disease, other autoimmune diseases are more frequent associated(p=0,02)  Autoimmune thyroid diseases aprear more frequently in women  Associated autoimmune diseases appear more frequently in men who were affected by a thyroid autoimmune disease. Conclusions

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