1. Excretory System Biology 20

3. Four Excretory Organs Excretion rids the body of metabolic wastes Kidneys are the primary excretory organ but other organs also function in excretion: skin, liver and lungs Sweat glands in skin secrete perspiration –Sweat is water, salt and some urea –Helps rid the body of waste products but mainly cools the body down by evaporation

4. Four Excretory Organs Liver excretes bile pigments –Bile pigments results from the breakdown of hemoglobin –Urochrome is yellow pigment derived from heme breakdown and is excreted by the kidneys –Liver also excretes cholesterol and excess fat-soluble vitamins

5. Four Excretory Organs Kidneys produce urine –Urine contains 95% water plus nitrogen wastes and inorganic salts –Nitrogenous wastes are products of metabolism of amino acids and nucleotides –Amino acid metabolism produces urea as main nitrogenous end products in humans

6. Urinary System Anatomy

7. Kidneys contribute to homeostasis, producing urine to rid body of nitrogenous wastes and keeping pH and salt/water balance of blood within normal range The Path of Urine –Kidneys Located on either side of the vertebral column just below the diaphragm Function is to produce urine

8. Urinary System Anatomy –Ureters Muscular tubes that run from the kidney to the bladder Transport urine by peristaltic contractions –Urinary Bladder Hollow muscular organ expands as urine enters Capacity of up to 600mL of urine Controlled by two sphincters where the urethra joins the bladder –Urethra Duct that transports urine from urinary bladder to the external opening

9. Urination and the Nervous System Urinary bladder fills with urine Stretch receptors send nerve impulses to the brain Nerve impulses from spinal cord causes the urinary bladder muscles to contact and the sphincters to relax making urination possible (micturating reflex)

10. Kidney Anatomy On concave side there is a depression where renal blood vessels and ureters enter Renal cortex is outer layer (filtration)

11. Renal Anatomy Renal medulla is the middle layer (reabsorption) with cone-shaped masses call renal pyramids Renal pelvis is central space or cavity that is continuous with the ureters

12. Kidney Anatomy

13. Nephrons Nephrons are microscopic Each kidney contains over one million nephrons Functional unit of the kidney Several nephrons enter one collecting duct

14. Afferent Arteriole Efferent Arteriole

15. Blood Flow Through the Nephron Renal Artery brings waste filled blood into the kidney Afferent arteriole is a dilated blood vessel leading into the glomerulus

16. Blood Flow Through the Nephron Glomerulus is a ball of capillaries responsible for blood filtration Efferent arteriole is a constricted blood vessel leaving the nephron Blood collects in the venules that joins the renal vein

17. Bowman’s Capsule Bowman’s capsule is a cup-like structure that encloses the glomerulus –Collects filtrate from the glomerulus –Process is called glomerular filtration –Found within the renal cortex

18. Proximal Convoluted Tubule Has large surface area for tubular reabsorption Tubular reabsorption is the transfer of water and solutes from the nephron to the surrounding capillaries Cells have many mitochondria to supply energy for active transport Found within the renal medulla

19. Loop of Henle Descending loop of Henle allows the reabsorption of water Ascending loop of Henle in impermeable to water

20. Distal Convoluted Tubule and Collecting Duct Distal Convoluted Tubule –Permeable to water in the presence of Antidiuretic Hormone Collecting Duct –Permeable to water in the presence of Antidiuretic Hormone

21. Filtration The first event to occur in urine formation is filtration of the blood Filtrate will include mostly water and dissolved solutes including wastes and nutrients –Afferent arteriole is dilated, which increases blood volume and pressure into the glomerulus –Efferent arteriole is constricted, which increases pressure as blood backs up in the glomerulus –Filtrate is collected by the Bowman’s capsule

22. Filtration You need a minimum of 70mmHg of systolic pressure for proper filtration to occur Extremely high blood pressure can damage the glomerulus and allow RBC and proteins to pass into the nephron

23. Urine Solute Concentration The nutrients and salts in the filtrate need to be reabsorbed into the bloodstream. This process includes: –60% of the solutes are reabsorbed by active transport at the proximal convoluted tubule –20% is reabsorbed by active transport at the loop of Henle –The remaining 20% is either reabsorbed at the distal convoluted tubule or excreted as part of the urine

24. Solute Concentration Bowman’s capsule 60% of solutes reabsorbed by active transport 20% of solutes reabsorbed by active transport 20% of solutes reabsorbed or excreted in the urine

25. Water Regulation The kidney filters about 180 to 200L of water a day 99% of the water is reabsorbed About 85% of the water diffuses out of the water permeable proximal convoluted tubule and descending loop of Henle and is reabsorbed by the capillaries

26. Water Regulation Osmoreceptors in the hypothalamus are stimulated by the high osmotic pressure in the blood. As a result the hypothalamus stimulates: –The adrenal gland to release the hormone aldosterone –The pituitary gland to release antidiuretic hormone (ADH) –And other areas in the brain to produce the sensation of thirst

27. Water Regulation At the ascending loop of Henle NaCl is actively transported out in the presence of the hormone Aldosterone The distal convoluted tubule and collecting duct become permeable to water in the presence of ADH The remaining 15% of water is reabsorbed based on osmotic pressure of the blood (regulated by ADH)

28. Water Regulation 85% Reabsorption by diffusion Reabsorption aided by ADH 15% Aldosterone ADH

29. Dialysis

30. Kidney Disease Diabetes Mellitus –Lack of insulin produced from the pancreas –Results in increased blood sugar levels, which in turn will result in increased sugar concentration in the nephron –Draws water into the nephron –Results in increased sugar and water in the urine

31. Kidney Disease Diabetes Insipidus –Destruction of ADH producing cells of the hypothalamus –No reabsorption of water – urine output increases dramatically (20L/day) –Must drink large quantities of water, regulated with injections of ADH

32. Kidney Disease Brights Disease (Nephritis) –Inflammation of the nephron –Proteins found in the urine Kidney Stones –The clumping and hardening of minerals from the blood –Must pass through pelvis  ureters  urinary bladder  urethra (painful in males)