1. Human Endocrine Physiology February 27, 2014

6. Sex Determination and Differentiation

7. SRY

10. AMH T

11. SRY Gene

13. Testicular Steroid Pathways Progesterone Pregnenolone Cholesterol 17OH-Prog 17OH-Preg T A4 LH/FSH

14. Conversion of Testosterone to Dihydrotestosterone

17. SRY AMH T

22. Conversion of Testosterone to Dihydrotestosterone

25. Adrenal Steroid Pathways Progesterone Pregnenolone Cholesterol Cortisol 17OH-Prog 17OH-PregDHEA Testosterone Androstenedione Aldosterone ACTH

26. Classical Congenital Adrenal Hyperplasia Progesterone Pregnenolone Cholesterol Cortisol 17OH-Prog 17OH-PregDHEA Testosterone Androstenedione Aldosterone ACTH * *21-hydroxylase loss of function mutation *

27. Classical Congenital Adrenal Hyperplasia Progesterone Pregnenolone Cholesterol Cortisol 17OH-Prog 17OH-Preg DHEA Testosterone Androstenedione Aldosterone ACTH * *21-hydroxylase loss of function mutation *

29. Human Endocrine Physiology: The Menstrual Cycle

34. Ovarian Physiology GnRH Pituitary Ovary LH FSH Inhibin Estrogens Progesterone Androgens

35. FSH Sex steroid Inhibin* + Gonadotropin Releasing Hormone (GnRH) + (pituitary) (hypothalamus) (ovary) LH - (+) *Inhibin exerts negative feedback only at the pituitary and only on FSH

40. Insulin

41. Ovarian Steroid Pathways Progesterone Pregnenolone Cholesterol 17OH-Prog 17OH-Preg T A4 LH/FSH Estrone Estradiol

43. *Only enzyme to know **

45. Changes in Hormones Across the Menstrual Cycle 0 Ov30 FSH

46. Changes in Hormones Across the Menstrual Cycle 0 Ov30 Estradiol

47. Changes in Hormones Across the Menstrual Cycle 0 Ov30 LH

49. Changes in Hormones Across the Menstrual Cycle 0 Ov30 Progesterone

53. Inhibin * * *LH receptors on granulosa cells induced by FSH

55. Changes in Hormones Across the Menstrual Cycle 0 Ov30 Inhibin

57. * * *LH receptors on granulosa cells induced by FSH

64. Functions of FSH During the Menstrual Cycle

65. Functions of LH During the Menstrual Cycle

66. Functions of Estradiol During the Menstrual Cycle

69. Functions of Progesterone During the Menstrual Cycle

70. Functions of Inhibin During the Menstrual Cycle

72. Changes in Hormones Across the Menstrual Cycle 0 Ov30