1. BEFORE WE START… 1) Add M&M to cup of water M SIDE UP 2) Set aside for later 3) DON’T TOUCH ANYTHING ELSE!

2. Chemistry & Biology Group Get in the mind set of… Amanda Brindley, Dean Tantillo, Jessica Renault, Justin Siegel, Mike Stekoll, Renee Link  Freshman or Sophomore  Intro Biology or Chemistry  First month  Left off at electronegativity

3. Consequences of Electronegativity Water Half & Half Oil 1.Place a few drops of food coloring in each cup 2.Discuss with your partner the effects observed

4. What molecular properties caused the observed effects?

5. Molecules Involved Water Milk Oil

6. Interactions between biological molecules where polarity matters Brainstorm with your group for 1 minute

7. C D A View into binding pocket of a protein B NOT TO SCALE… base decisions on Molecular Properties Which would most likely bind in the pocket depicted below?

8. View into binding pocket of a protein NOT TO SCALE… base decisions on Molecular Properties Which would most likely bind in the pocket depicted below? C D AB

9. View into binding pocket of a protein NOT TO SCALE… base decisions on Molecular Properties Which would most likely bind in the pocket depicted below? C D AB

10. C D A View into binding pocket of a protein B NOT TO SCALE… base decisions on Molecular Properties Which would most likely bind in the pocket depicted below?

11. What we learned… Structure  Properties  Function 1) Electronegativity affects polarity 2) Polarity influences molecular interactions

12. Milk… Dye… Soap… 1.Cover bottom with Half&Half 2.Drip dye in center 3.Dip Q-tip into soap dish 4.Place the Q-tip in center of dye 5.WATCH & Record observations 6.Have fun ;) Homework: What other experiments would you design to help figure out what is happening?

13. Setup for your class…