1. Welcome to Berlin, Welcome to PhUSE 2010

2. Welcome PhUSE and PhUSE Conferences so far Conference Agenda Thanks to our Sponsors and Exhibitors Keynote Speakers

3. PhUSE and PhUSE Conferences 2005, Annual Conference in Heidelberg (Stephen Bamford) 60 presentations, 270 delegates. 2006, Annual Conference in Dublin (Stephen Bamford) 85 presentations, 290 delegates. 2007, Annual Conference in Lisbon (Dirk Spruck) 86 presentations, 270 delegates; Invasion of Yellow Alfreds.

4. PhUSE and PhUSE Conferences 2008, PhUSE became a Society and had 503 Society Members; PhUSE started organizing Single Day Events: 2 in London, 1 in Basel; Annual Conference in Manchester (Olivier Leconte)  98 presentations, 300 delegates;  Invasion of Red Alfreds. 2009, 651 Society Members; 6 SDEs, Basel, Brussels, Frankfurt, Uxbridge, 2 in London; Annual Conference in Basel (Ben Szilagyi)  123 presentations, 390 delegates;  2 Pre-Conference trainings;  3 Discussion Clubs;  Invasion of Blue Alfreds.

5. PhUSE and PhUSE Conferences 2010 1047 Society Members; 5 SDEs, Basel, Brussels, Copenhagen, Welwyn Garden City, Boston; Berlin  115 presentations, 362 delegates;  2 Pre-Conference trainings;  3 Keynote speakers;  3 Discussion Clubs;  6 Regional Discussion Clubs.

6. PhUSE is THE Shining Light

7. Innovation Driven by Technology With the explosive growth of standards, the drive to increase efficiency and reduce costs, and the development of new and complex study designs, it is in the interests of most companies and organizations to seek solutions from innovations linked to development of the latest technologies.

8. Innovation Driven by Technology Innovating is doing something in a new, unexpected way but do we need brand-new technology to be innovative?

9. Will innovations save money and increase productivity without being extremely expensive? Innovation Driven by Technology

10. Will they result in business transformation or can innovations be subtle? Innovation Driven by Technology

11. Conference Agenda Sunday, October 17 th : Pre-Conference Trainings:  CDISC Workshop (Business and Decision);  Elementary Statistics for SAS Programmers (Amadeus); Welcome Drink and Dinner. Monday, October 18 th : Plenary Session with Dr.Rebecca Kush and Dr.Charles Jaffe; Parallel Streams in 4 rooms:  Saphir I: Technical Solutions;  Saphir II: Statistics and Pharmacokinetics;  Rubin: CDISC and Industry Standards;  Aquamarin: Management Stream.

12. Closing the Monday in Style Louging, Dining, Clubbing, Dancing the evening away.... Wasserwerk, an old industrial pump house. Coaches will depart from the front of the Radisson Blu at 7pm.

13. Conference Agenda Tuesday, October 19 th : Secondary Plenary Session with Dr.Ed Conley; Discussion Clubs in Aquamarin:  CDISC and Industry Standards;  Outsourcing;  Innovation Driven by Technology. We hope to get some interaction with you…

14. Conference Agenda Tuesday, October 19 th : Saphir I: Technical Solutions, Data Handling, RDC UK; Saphir II: Applications and Software Development, RDC Switzerland; Rubin: CDISC and Industry Standards, Professional Development and Training, Tutorials, RDC Germany; Aquamarin: Coder’s Corner, RDC Rest of Europe; DomLounge, with wine and cheese: Posters. Wednesday, October 20 th : AGM in Rubin; Saphir I: Data Handling, Professional Development and Training, RDC Benelux; Saphir II: Regulatory, RDC Scandinavia; Rubin: Tutorials, Coding Solutions, RDC Rest of World; Aquamarin: University Day; Closing Session.

15. Conference Agenda On all days, in all rooms, at all floors We hope you will share your knowledge and experience; We trust you will contribute to debates and discussions; We count on you to give us feedback, in order to continue improving PhUSE’s events. At all times, in the exhibition area, a member of the Conference Committee or the Board of Directors will be available for you at the PhUSE stand. We welcome any question, any suggestion, just a little talk to get to know you and your wishes.

17. Thanks

20. Stream (Co-)Chairs Jean-Marc and Pierre Frans and Michael Jules and Berber Sascha and Gavin Louise and Roy Jennie and Tangi Kathryn and Alison Beate and Stephen Fritz and Martin Ian and Mike Antoine and Dominique Dave and James Regional Discussion Clubs Olivier and his team: – Dirk – Jerry – Michael – Ann – Jean-Marc – Roy – Francis Discussion Clubs Christian David Michael and Frans

21. Dr. Charles Jaffe MD, PhD, FACMI CEO, Health Level 7

22. Dr. Rebecca D. Kush, PhD President and CEO, CDISC

23. Dr. Ed Conley Principal Investigator, Cardiff University